Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1.1Axbe mutation
(2 available);
any
Fbxw7 mutation
(82 available)
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
Tg(En2-cre)22Alj mutation
(1 available)
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nervous system
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• Purkinje cells exhibit partial rescue of organization and arborization compared with Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe Tg(En2-cre)22Alj mice
• however, Purkinje cell density is rescued
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• partially rescued compared with Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe Tg(En2-cre)22Alj mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1.1Axbe mutation
(2 available);
any
Fbxw7 mutation
(82 available)
Juntm2.1Wag mutation
(0 available);
any
Jun mutation
(12 available)
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
Tg(En2-cre)22Alj mutation
(1 available)
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nervous system
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• Purkinje cells exhibit partial rescue of organization and arborization compared with Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe Tg(En2-cre)22Alj mice
• however, Purkinje cell density is rescued
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Sev mutation
(1 available);
any
Isl1 mutation
(33 available)
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
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mortality/aging
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N |
• mice are present at the expected Mendelian ratios at E14.5-P0, indicating normal embryonic survival
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cardiovascular system
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• at E14.5 to P0, seven of 22 (32%) embryos exhibit aortic arch artery remodeling defects, including interrupted aortic arch (IAA) type B, hypoplasia of the B segment of the aortic arch, and aberrant retro-esophageal right subclavian artery
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• at E14.5 to P0, seven of 22 (32%) embryos exhibit aberrant retro-esophageal right subclavian artery
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• at E14.5 to P0, seven of 22 (32%) embryos exhibit interrupted aortic arch (IAA) type B
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• at E14.5 to P0, seven of 8 (88%) embryos exhibit outflow tract (OFT) defects, including ventricular septal defect (VSD), double outlet right ventricle, and semilunar valve hyperplasia
• a non-significant trend toward a decrease in proliferating pHH3+ cells and an increase in apoptotic TUNEL+ cells is noted in the OFT at E10.5
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• at E14.5 to P0, seven of 8 (88%) embryos exhibit DORV
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• at E14.5 to P0, seven of 8 (88%) embryos exhibit VSDs
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• at E14.5 to P0, six of 8 (75%) embryos exhibit an aortic valve defect
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• at E14.5 to P0, seven of 8 (88%) embryos exhibit a pulmonary valve defect
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• at PO, pulmonary valve leaflets are enlarged and hyperplastic
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• at E14.5 to P0, seven of 8 (88%) embryos exhibit semilunar valve hyperplasia
• however, atrioventricular (mitral and tricuspid) valves are unaffected
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embryo
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• at E14.5 to P0, seven of 22 (32%) embryos exhibit aortic arch artery remodeling defects, including interrupted aortic arch (IAA) type B, hypoplasia of the B segment of the aortic arch, and aberrant retro-esophageal right subclavian artery
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craniofacial
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• at E14.5 to P0, seven of 22 (32%) embryos exhibit aortic arch artery remodeling defects, including interrupted aortic arch (IAA) type B, hypoplasia of the B segment of the aortic arch, and aberrant retro-esophageal right subclavian artery
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cardiovascular system
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N |
• at E10.5, embryos show normal expression of Nfatc1 (an endocardial marker) relative to controls, suggesting normal endocardial formation
• a non-significant trend toward a decrease in proliferating pHH3+ cells and an increase in apoptotic TUNEL+ cells is noted in the cardiac outflow tract (OFT) at E10.5
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embryo
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N |
• at E10.5, embryos show normal expression of Tfap2a during cardiac OFT development relative to controls, suggesting normal cardiac neural crest cell migration
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm1Pa mutation
(1 available);
any
Jun mutation
(12 available)
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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embryo
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N |
• at E10.5, embryos show a similar pattern of Tfap2a expression in the developing cardiac outflow tract (OFT) and pharyngeal arches relative to controls, suggesting normal cardiac neural crest cell migration
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
Tg(Nes-cre)1Wme mutation
(1 available)
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mortality/aging
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• 2% of animals survive to weaning
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• animals born at less than the predicted Mendelian ratio
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growth/size/body
skeleton
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• fusion of neural arches
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vision/eye
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• severity of phenotype was variable
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
Tg(COL2A1-cre)1Wag mutation
(0 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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liver/biliary system
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• following induction with IFN or pI-pC and 70% partial hepatectomy, abnormal architecture, hepatocyte death, and accumulation of cytoplasmic fat droplets were observed in the regenerating liver
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
Tg(Sftpc-cre)1Blh mutation
(0 available)
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cellular
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• mutants exhibit an increase in apoptotic cells in the lungs
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respiratory system
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• mutants exhibit an increase in apoptotic cells in the lungs
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• mutants exhibit infiltration of atypical foamy alveolar macrophages
• mutants with prolonged exposure to cigarette smoke exhibit perivascular and peribronchiolar inflammation
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• 3 month old mutants exhibit enlarged air spaces and infiltration of atypical foamy alveolar macrophages
• progressive destruction of alveolar tissue
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• mutants develop progressive emphysema
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• localized destruction leading to large cavities in the parenchyma
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immune system
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• elevated levels of IL-12p40, IL-13, and CXCL1 cytokines in the BAL
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• an elevated level of TNF-alpha is seen in the BAL fluid
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• mutants exhibit infiltration of atypical foamy alveolar macrophages
• mutants with prolonged exposure to cigarette smoke exhibit perivascular and peribronchiolar inflammation
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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nervous system
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N |
• cultured neurons exhibit normal degeneration induced by NGF withdrawal
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• in culture following NGF withdrawal
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cellular
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• in culture following NGF withdrawal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1.1Axbe mutation
(2 available);
any
Fbxw7 mutation
(82 available)
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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nervous system
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• neurosphere apoptosis is decreased compared to in Fbxw7tm1Axbe/Fbxw7tm1Axbe Tg(Nes-cre)1Kln mice
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• the cellularity defect in the mantle layer of the midbrain tectum observed in Fbxw7tm1Axbe/Fbxw7tm1Axbe Tg(Nes-cre)1Kln mice is rescued
• the number of stem cells in the tectal ventricular zone is increased compared to in wild-type mice
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cellular
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• neurosphere apoptosis is decreased compared to in Fbxw7tm1Axbe/Fbxw7tm1Axbe Tg(Nes-cre)1Kln mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Junbtm3Wag mutation
(1 available);
any
Junb mutation
(19 available)
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
Tg(Krt1-5-cre/ERT)1Ipc mutation
(0 available)
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integument
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• intra-epidermal T cells, epidermal micro-abscesses and typical inflammatory-cell infiltrate consisting of neutrophils, and an increase in numbers of macrophages in the dermis are seen in mice 8-10 days after tamoxifen induction
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• mice treated with tamoxifen show an increase in subepidermal vascularization
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• thickening of keratinized upper layers in mice treated with tamoxifen
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• in mice treated with tamoxifen
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• mice treated with tamoxifen show thickened epidermis with prominent rete ridge
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• mice treated with tamoxifen at 8 weeks of age develop psoriasis-like skin lesions on hairless skin 8-10 days after tamoxifen induction, showing scaly plaques affecting primarily ears, paws and tail, and less frequently the hairy back skin
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immune system
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• periostitis in mice treated with tamoxifen
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• arthritic lesions similar to psoriatic arthritis are seen in 100% of mice treated with tamoxifen, showing inflammatory infiltrates in joint regions
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• intra-epidermal T cells, epidermal micro-abscesses and typical inflammatory-cell infiltrate consisting of neutrophils, and an increase in numbers of macrophages in the dermis are seen in mice 8-10 days after tamoxifen induction
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skeleton
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• arthritic lesions similar to psoriatic arthritis are seen in 100% of mice treated with tamoxifen, showing inflammatory infiltrates in joint regions
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• massive bone destruction
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• periostitis in mice treated with tamoxifen
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cardiovascular system
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• mice treated with tamoxifen show an increase in subepidermal vascularization
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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mortality/aging
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N |
• mice are present at the expected Mendelian ratios at E15.5-P0, indicating normal embryonic survival until late gestation or even until birth
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cardiovascular system
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N |
• at E15.5-P0, none of 10 mice examined exhibit any aortic arch artery remodeling defects
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• at E15.5, three of 7 (43%) embryos show thinning of the compact myocardium of the right ventricle
• however, no compact zone thinning is noted in the left ventricle
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• at E15.5-P0, one of 7 (14%) embryos exhibits a double outlet right ventricle (DORV)
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• at E15.5, mitral valve leaflets are thickened and hyperplastic in one embryo
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• at E15.5-P0, one of 7 (14%) embryos shows mitral valve hyperplasia
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• at E15.5-P0, three of 7 (43%) embryos show a perimembranous VSD
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• at P0, pulmonary valve leaflets are thickened and hyperplastic in one embryo
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• at E15.5-P0, one of 7 (14%) embryos shows pulmonary valve hyperplasia
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muscle
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• at E15.5, three of 7 (43%) embryos show thinning of the compact myocardium of the right ventricle
• however, no compact zone thinning is noted in the left ventricle
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
Tg(Alb1-cre)7Gsc mutation
(1 available)
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growth/size/body
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• animals displayed reduced body weight at 2 weeks of age that persisted into adulthood
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liver/biliary system
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• following 70% partial hepatectomy, large areas of necrotic tissues were observed in the regenerating liver
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Sev mutation
(1 available);
any
Isl1 mutation
(33 available)
Juntm4Wag mutation
(0 available);
any
Jun mutation
(12 available)
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cardiovascular system
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• at E14.5 to P0, a single embryo (1 of 22) shows IAA type B
• however, no other OFT or aortic arch abnormalities are observed
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Analysis Tools