Phenotypes associated with this allele

• Allele Symbol: Rr349^tm1Wgw
• Allele Name: targeted mutation 1, William G Wood
• Allele ID: MGI:2445391
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr349^tm1Wgw/Rr349^tm1Wgw	involves: 129P2/OlaHsd	MGI:3721063
ht2	Rr349^tm1Wgw/Rr349^+	involves: 129P2/OlaHsd	MGI:3721061

Genotype
MGI:3721063

hm1

• Allelic Composition: Rr349^tm1Wgw/Rr349^tm1Wgw
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:80121 )

• homozygotes died between 13.5 and 15.5 days

hematopoietic system

anemia ( J:80121 )

• severe anemia in dyeing fetuses

abnormal erythrocyte morphology ( J:80121 )

• 14.5 days fetal blood showed marked dyserythropoiesis and an increased portion of yolk sac erythroid cells

abnormal hemoglobin ( J:80121 )

• ratio of alpha-globin RNA to beta-globin RNA was reduced

liver/biliary system

abnormal liver development ( J:80121 )

• reduced fetal liver size with considerable dyserythropoiesis

integument

pallor ( J:80121 )

• homozygous fetuses were recognizable from their obvious pallor

Genotype
MGI:3721061

ht2

• Allelic Composition: Rr349^tm1Wgw/Rr349⁺
• Genetic Background: involves: 129P2/OlaHsd

hematopoietic system

abnormal hemoglobin ( J:80121 )

• ratio of alpha-globin RNA to beta-globin RNA was reduced to approximately 70.1% of normal, consistent with the presence of alpha thalassemia

decreased hemoglobin content ( J:80121 )

decreased mean corpuscular hemoglobin ( J:80121 )

decreased mean corpuscular volume ( J:80121 )

anisocytosis ( J:80121 )

poikilocytosis ( J:80121 )