Rr349^tm1Wgw
Targeted Allele Detail

Summary

• Symbol: Rr349^tm1Wgw
• Name: regulatory region 349; targeted mutation 1, William G Wood
• MGI ID: MGI:2445391
• Synonyms: floxed mHS -26^-, Hba/Mare^tm1Wgw, Mare^tm1Wgw, Nprl3^tm1Wgw
• Gene: Rr349 Location: Chr11:32200804-32201369 bp Genetic Position: Chr11, Syntenic
• Alliance: Rr349^tm1Wgw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80121
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1312 bp sequence containing the Hba erythroid regulatory element (HS -26), located in Nprl3 intron 4 and containing transcription factor binding elements for the hemoglobin alpha genes, was replaced with a loxP site flanked neomycin resistance gene cassette. Expression of the Nprl3 gene was severely down-regulated although the open reading frame of the gene was not disrupted. (J:80121)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr349 Mutation: 0 strains or lines available

References

• Original: J:80121 Anguita E, et al., Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype. Blood. 2002 Nov 15;100(10):3450-6
• All: 1 reference(s)