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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atf2+
wild type
MGI:2440896
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Atf2tm1b(EUCOMM)Hmgu/Atf2+ C57BL/6N-Atf2tm1b(EUCOMM)Hmgu/Ccpcz MGI:6408251
ht2
 		Atf2tm1Glm/Atf2+ involves: 129S2/SvPas MGI:3046342
ht3
 		Atf2Tg(Gzma-Klra1)7Wum/Atf2+ involves: C57BL/6 MGI:3813926
cx4
 		Atf2tm1Sis/Atf2+
Creb5tm1Sis/Creb5+ 		involves: C57BL/6 * CBA MGI:4421139


Genotype
MGI:6408251
ht1
Allelic
Composition		 Atf2tm1b(EUCOMM)Hmgu/Atf2+
Genetic
Background		 C57BL/6N-Atf2tm1b(EUCOMM)Hmgu/Ccpcz
Cell Lines HEPD0756_7_A01
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm1b(EUCOMM)Hmgu mutation (0 available); any Atf2 mutation (89 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
enlarged heart ( J:211773 )
IMPC - CCP-IMG

endocrine/exocrine glands
small testis ( J:211773 )
IMPC - CCP-IMG

growth/size/body
enlarged heart ( J:211773 )
IMPC - CCP-IMG
decreased body weight ( J:211773 )
IMPC - CCP-IMG

hematopoietic system

homeostasis/metabolism

immune system

integument

renal/urinary system

reproductive system
small testis ( J:211773 )
IMPC - CCP-IMG




Genotype
MGI:3046342
ht2
Allelic
Composition		 Atf2tm1Glm/Atf2+
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm1Glm mutation (1 available); any Atf2 mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:30611 )
• heterozygous mice are phenotypically normal but display an increased postnatal mortality rate that is roughly half that of homozygotes, consistent with a gene dosage effect




Genotype
MGI:3813926
ht3
Allelic
Composition		 Atf2Tg(Gzma-Klra1)7Wum/Atf2+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2Tg(Gzma-Klra1)7Wum mutation (1 available); any Atf2 mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:61178 )
N
• mice exhibit normal numbers and functions of lymphocytes other than NK cells
• despite the reduction in NK cells and function, mice exhibit a normal generalized Shwartzman reaction and normal antibody response to TI type 2 antigen exposure
decreased NK cell number ( J:61178 )
• mice exhibit a reduction in the number of NK1.1+ CD3- spleen cells compared to in wild-type mice
• NK1.1+ CD3- cells are virtually absent from the peripheral blood
decreased NK T cell number ( J:61178 )
• slight decrease in the spleen
abnormal NK cell physiology ( J:61178 )
• unlike in wild-type mice, splenocytes lack natural killing activity towards YAC-1
• mice fail to clear injected tumor cells as do wild-type mice
decreased circulating interferon-gamma level ( J:61178 )
• following injection with LPS, serum levels of IFN-gamma are lower than in similarly treated wild-type mice
• however, mice produce normal levels of IFN-gamma in response to exposure to IL-12

neoplasm
increased metastatic potential ( J:61178 )
• when injected with B16 tumor cells, mice exhibit a greater than 60-fold higher number of lung metastases compared to in similarly treated wild-type mice
• however, the number of liver metastases is normal following injection with B16 tumor cells

cardiovascular system
abnormal artery development ( J:134875 )
• mice exhibit impaired arteriogenesis following occlusion compared to in similarly treated wild-type mice

homeostasis/metabolism
decreased circulating interferon-gamma level ( J:61178 )
• following injection with LPS, serum levels of IFN-gamma are lower than in similarly treated wild-type mice
• however, mice produce normal levels of IFN-gamma in response to exposure to IL-12

hematopoietic system
decreased NK cell number ( J:61178 )
• mice exhibit a reduction in the number of NK1.1+ CD3- spleen cells compared to in wild-type mice
• NK1.1+ CD3- cells are virtually absent from the peripheral blood
decreased NK T cell number ( J:61178 )
• slight decrease in the spleen
abnormal NK cell physiology ( J:61178 )
• unlike in wild-type mice, splenocytes lack natural killing activity towards YAC-1
• mice fail to clear injected tumor cells as do wild-type mice




Genotype
MGI:4421139
cx4
Allelic
Composition		 Atf2tm1Sis/Atf2+
Creb5tm1Sis/Creb5+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm1Sis mutation (2 available); any Atf2 mutation (89 available)
Creb5tm1Sis mutation (1 available); any Creb5 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
adipose tissue phenotype ( J:156376 )
N
• unlike in white adipose tissue, no defects are detected in the brown adipose tissue
decreased subcutaneous adipose tissue amount ( J:156376 )
• decrease in the weight of subcutaneous WAT relative to total body weight compared to wild-type controls
decreased white adipose tissue amount ( J:156376 )
• decrease in WAT weight compared to wild-type controls
• decrease in the weight of visceral WAT relative to total body weight compared to wild-type controls

homeostasis/metabolism
improved glucose tolerance ( J:156376 )
• display less high fat diet induced hyperglycemia in an intraperitoneal glucose tolerance test
increased insulin sensitivity ( J:156376 )
• hypoglycemic response to insulin is increased compared to wild-type controls

cellular
abnormal cell differentiation ( J:156376 )
• MEFs display reduced adipocyte differentiation compared to wild-type cells

behavior/neurological
behavior/neurological phenotype ( J:156376 )
N
• despite the decrease in white adipose tissue weight, no difference in cumulative food intake is detected

growth/size/body
growth/size/body region phenotype ( J:156376 )
N
• despite the decrease in white adipose tissue weight, no difference in total body weight is detected

integument
decreased subcutaneous adipose tissue amount ( J:156376 )
• decrease in the weight of subcutaneous WAT relative to total body weight compared to wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory