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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim29+
wild type
MGI:2440730
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
Trim29tm1c(EUCOMM)Wtsi/Trim29+
Trp53tm1Brn/Trp53+ 		involves: 129 * C57BL/6 * CBA MGI:8192944


Genotype
MGI:8192944
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Tg(Pdx1-cre)89.1Dam/0
Trim29tm1c(EUCOMM)Wtsi/Trim29+
Trp53tm1Brn/Trp53+
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (24 available); any Gt(ROSA)26Sor mutation (1243 available)
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)
Trim29tm1c(EUCOMM)Wtsi mutation (0 available); any Trim29 mutation (29 available)
Trp53tm1Brn mutation (20 available); any Trp53 mutation (247 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:289183 )
• average survival is 8.5 +/- 2.3 months

neoplasm
decreased gland tumor incidence ( J:289183 )
• initiation and progression of acinar-ductal metaplasia and pancreatic intraepithelial neoplasia (PanIN) lesions are slower than in Krastm4Tyj/Kras+ Trp53tm1Brn/Trp53+ Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ (KPCY) mice
• mice show lower pancreatic ductal adenocarcinoma and metastasis incidence than in KPCY mice
decreased metastatic potential ( J:289183 )
• mice show lower lung and liver metastasis from pancreatic ductal adenocarcinoma than in KPCY mice

endocrine/exocrine glands
decreased gland tumor incidence ( J:289183 )
• initiation and progression of acinar-ductal metaplasia and pancreatic intraepithelial neoplasia (PanIN) lesions are slower than in Krastm4Tyj/Kras+ Trp53tm1Brn/Trp53+ Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ (KPCY) mice
• mice show lower pancreatic ductal adenocarcinoma and metastasis incidence than in KPCY mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/06/2026
MGI 6.29 		The Jackson Laboratory