All Phenotypes Cbl<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cbl⁺
wild type
MGI:2440296

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cbl^{tm1b(EUCOMM)Hmgu}/Cbl⁺	C57BL/6N-Cbl^{tm1b(EUCOMM)Hmgu}/Orl	MGI:6771952
ht2	Cbl^tm1Ddlb/Cbl⁺	involves: 129S1/Sv * C57BL/6	MGI:3623292
cx3	Cbl^tm1Soga/Cbl⁺ Tg(Tec-BCR/ABL1)5Hhi/0	involves: C57BL/6 * DBA/2	MGI:4354767

Allelic Composition	Cbl^{tm1b(EUCOMM)Hmgu}/Cbl⁺
Genetic Background	C57BL/6N-Cbl^{tm1b(EUCOMM)Hmgu}/Orl
Cell Lines	HEPD0672_6_B06

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbl^{tm1b(EUCOMM)Hmgu} mutation (0 available); any Cbl mutation (57 available)

Data Sources

IMPC Data for Cbl

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

thick ventricular wall ( J:211773 )

IMPC - ICS

prolonged PR interval ( J:211773 )

IMPC - ICS

Allelic Composition	Cbl^tm1Ddlb/Cbl⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbl^tm1Ddlb mutation (3 available); any Cbl mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:121012 )

• after 4 weeks on a high-fat diet, male mice are on average 3.5 g heavier than male Cbl^tm1Wlan/ Cbl^tm1Ddlb littermates

increased susceptibility to diet-induced obesity ( J:121012 )

• on a high fat diet (60% of caloric intake from fat) for 4 weeks, male mice gain more weight (3.5 g) than Cbl^tm1Wlan/ Cbl^tm1Ddlb littermates (1.5g)

adipose tissue

decreased white adipose tissue amount ( J:94416 )

• 30% decrease in epididymal white fat mass compared to wild-type mice

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:121012 )

• on a high fat diet (60% of caloric intake from fat) for 4 weeks, male mice gain more weight (3.5 g) than Cbl^tm1Wlan/ Cbl^tm1Ddlb littermates (1.5g)

improved glucose tolerance ( J:121012 )

• male mice show modestly enhanced glucose clearance relative to wild-type controls

Allelic Composition	Cbl^tm1Soga/Cbl⁺ Tg(Tec-BCR/ABL1)5Hhi/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbl^tm1Soga mutation (0 available); any Cbl mutation (57 available)
Tg(Tec-BCR/ABL1)5Hhi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:151543 )

• mice die prematurely with accelerated blast crisis compared to in Tg(BCR/ABL1)5Hhi mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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