Phenotypes associated with this allele

• Allele Symbol: Slc17a6⁺
• Allele Name: wild type
• Allele ID: MGI:2440267
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Slc17a6^tm1Lex/Slc17a6^+	involves: 129S5/SvEvBrd * C57BL/6	MGI:3694784
cn2	Mc4r^tm2Lowl/Mc4r^tm2Lowl Slc17a6^tm2(cre)Lowl/Slc17a6^+	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5609673
cn3	Mc4r^tm1Lowl/Mc4r^tm1Lowl Slc17a6^tm2(cre)Lowl/Slc17a6^+	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5609677
cn4	Lepr^tm1.1Chua/Lepr^tm1.1Chua Slc17a6^tm2(cre)Lowl/Slc17a6^+	involves: 129S6/SvEvTac	MGI:5142145

Genotype
MGI:3694784

ht1

• Allelic Composition: Slc17a6^tm1Lex/Slc17a6⁺
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal miniature excitatory postsynaptic currents ( J:116159 )

• thalmic miniature EPSC amplitude is intermediate between wild-type and homozygous mice

behavior/neurological

abnormal conditioned taste aversion behavior ( J:116159 )

• time to extinction with repeated exposures is shorter in especially in low-responder heterozygotes compared to wild-type mice

abnormal locomotor activation ( J:116159 )

• bury fewer marbles; however activity in the home cage and results in the open field, rotarod, elevated plus maze, social interaction, passive avoidance learning, Morris water maze, and context-dependent fear conditioning tests are all similar to wild-type mice

abnormal pain threshold ( J:116159 )

• in the spared nerve injury model of neuropathic pain mechanical allodynia is absent in males and significantly reduced in females compared to wild-type mice

• in the spared nerve injury model of neuropathic pain cold allodynia is absent in females and significantly reduced in males compared to wild-type mice

Genotype
MGI:5609673

cn2

• Allelic Composition: Mc4r^tm2Lowl/Mc4r^tm2Lowl; Slc17a6^tm2(cre)Lowl/Slc17a6⁺
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

adipose tissue

increased total body fat amount ( J:216397 )

• increased fat mass

behavior/neurological

polyphagia ( J:216397 )

growth/size/body

obese ( J:216397 )

increased body length ( J:216397 )

Genotype
MGI:5609677

cn3

• Allelic Composition: Mc4r^tm1Lowl/Mc4r^tm1Lowl; Slc17a6^tm2(cre)Lowl/Slc17a6⁺
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

growth/size/body

growth/size/body region phenotype ( J:216397 )

N • rescue of the increased weight gain, of the fat stores, of hyperphagia and of the increased linear length seen in single Mc4r homozygotes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:216397 )

N • mice show normalization of the hyperglycemia and hyperinsulinemia that is seen in single Mc4r homozygotes

respiratory system

respiratory system phenotype ( J:216397 )

N • rescue of the depressed respiratory exchange ratio seen in single Mc4r homozygotes

Genotype
MGI:5142145

cn4

• Allelic Composition: Lepr^tm1.1Chua/Lepr^tm1.1Chua; Slc17a6^tm2(cre)Lowl/Slc17a6⁺
• Genetic Background: involves: 129S6/SvEvTac

growth/size/body

growth/size/body region phenotype ( J:174691 )

N • animals do not show significant changes in body weight up to 11 weeks of age

behavior/neurological

behavior/neurological phenotype ( J:174691 )

N • food intake shows no significant difference compared to controls

nervous system

nervous system phenotype ( J:174691 )

N • deletion of Lepr in Slc17a6 neurons does not alter IPSC amplitude in Agrp neurons; IPSC frequency is decreased (not significantly) in Agrp

N • excitatory postsynaptic currents (sEPSCs and mEPSCs) in Pomc1 neurons are not affected by Lepr deletion in Slc17a6 (glutamatergic) neurons

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:174691 )

N • fed and fasted blood glucose levels are unchanged and serum insulin levels are only slightly increased in the fed state

adipose tissue

adipose tissue phenotype ( J:174691 )

N • no increase in fat mass is observed at 10 weeks