Phenotypes associated with this allele

• Allele Symbol: Calca⁺
• Allele Name: wild type
• Allele ID: MGI:2440052
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	\Calca^tm1.1(EGFP/HBEGF)Mjz/\Calca^+	B6.Cg-Calca^tm1.1(EGFP/HBEGF)Mjz	MGI:5437494
ht2	\Calca^tm1.1(cre/EGFP)Rpa/\Calca^+	involves: 129S6/SvEvTac * C57BL/6NCrl	MGI:5559750
cn3	\Calca^tm1.1(cre/ERT2)Ptch/\Calca^+ \Trp53^tm1Brn/\Trp53^tm1Brn \Rb1^tm2Brn/\Rb1^tm2Brn \Pten^tm1Hwu/\Pten^tm1Hwu	involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N	MGI:5460854
cn4	\Calca^tm1.1(cre/ERT2)Ptch/\Calca^+ \Trp53^tm1Brn/\Trp53^tm1Brn \Rb1^tm2Brn/\Rb1^tm2Brn	involves: 129 * 129P2/OlaHsd * FVB/N	MGI:5460840
cn5	\Gt(ROSA)26Sor^tm1(DTA)Jpmb/\Gt(ROSA)26Sor^+ \Calca^tm1.1(cre/ERT2)Ptch/\Calca^+	involves: 129P2/OlaHsd * 129S/SvEv	MGI:5460837

Genotype
MGI:5437494

ht1

• Allelic Composition: \Calca^{tm1.1(EGFP/HBEGF)Mjz}/\Calca⁺
• Genetic Background: B6.Cg-Calca^{tm1.1(EGFP/HBEGF)Mjz}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:187267 )

• mice are viable with no obvious phenotypic or behavioral abnormalities

Genotype
MGI:5559750

ht2

• Allelic Composition: \Calca^{tm1.1(cre/EGFP)Rpa}/\Calca⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl

behavior/neurological

decreased food intake ( J:206070 )

• when neurons of the outer external lateral subdivision of the PBN (PBelo) are transduced with a cre-dependent channelrhodopsin-mCherry vector, photostimulation of projections to the central nucleus of the amygdala (CeAlc) reversibly suppressed food intake in animals whereas stimulation of PBelo projections to the bed nucleus of the stria terminalis (BNST) does not alter food intake significantly

nervous system

abnormal excitatory postsynaptic currents ( J:206070 )

• in mice injected with a cre-dependent channelrhodopsin (ChR2)-mCherry vector, optical stimulation of transduced fibers in the central nucleus of the amygdala (CeAlc) induces excitatory postsynaptic currents as well as increased firing rates in these neurons in acute brain slices

Genotype
MGI:5460854

cn3

• Allelic Composition: \Calca^{tm1.1(cre/ERT2)Ptch}/\Calca⁺; \Trp53^tm1Brn/\Trp53^tm1Brn; \Rb1^tm2Brn/\Rb1^tm2Brn; \Pten^tm1Hwu/\Pten^tm1Hwu
• Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

mortality/aging

postnatal lethality ( J:190366 )

• death within 3 months of tamoxifen treatment

respiratory system

increased lung small cell carcinoma incidence ( J:190366 )

• small cell lung tumors 2.5 months after tamoxifen treatment

abnormal pulmonary neuroendocrine body morphology ( J:190366 )

• increased proliferation of pulmonary neuroendocrine cells

neoplasm

increased thyroid tumor incidence ( J:190366 )

• all mice develop thyroid tumors

increased metastatic potential ( J:190366 )

• increased invasiveness at 2.5 months after tamoxifen treatment

increased lung small cell carcinoma incidence ( J:190366 )

• small cell lung tumors 2.5 months after tamoxifen treatment

endocrine/exocrine glands

increased thyroid tumor incidence ( J:190366 )

• all mice develop thyroid tumors

Genotype
MGI:5460840

cn4

• Allelic Composition: \Calca^{tm1.1(cre/ERT2)Ptch}/\Calca⁺; \Trp53^tm1Brn/\Trp53^tm1Brn; \Rb1^tm2Brn/\Rb1^tm2Brn
• Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

mortality/aging

postnatal lethality ( J:190366 )

• death within 6-7 months of tamoxifen treatment

respiratory system

increased lung small cell carcinoma incidence ( J:190366 )

• small cell lung tumors 5-6 months after tamoxifen treatment in 4 of 32 mice examined, all with pulmonary neuroendocrine cells hyperplasia as well

abnormal pulmonary neuroendocrine body morphology ( J:190366 )

• pulmonary neuroendocrine cells hyperplasia 5-6 months after tamoxifen treatment in 16 of 32 mice examined

• increased proliferation of pulmonary neuroendocrine cells

neoplasm

increased thyroid tumor incidence ( J:190366 )

• all mice develop thyroid tumors

increased lung small cell carcinoma incidence ( J:190366 )

• small cell lung tumors 5-6 months after tamoxifen treatment in 4 of 32 mice examined, all with pulmonary neuroendocrine cells hyperplasia as well

endocrine/exocrine glands

increased thyroid tumor incidence ( J:190366 )

• all mice develop thyroid tumors

Genotype
MGI:5460837

cn5

• Allelic Composition: \Gt(ROSA)26Sor^tm1(DTA)Jpmb/\Gt(ROSA)26Sor⁺; \Calca^{tm1.1(cre/ERT2)Ptch}/\Calca⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

respiratory system

abnormal club cell morphology ( J:190366 )

• clara cell numbers recover after tamoxifen and/or naphthalene lung injury regardless of presence or absence of pulmonary neuroendocrine cells

abnormal pulmonary neuroendocrine body morphology ( J:190366 )

• pulmonary neuroendocrine cells ablated by tamoxifen treatment are not replaced at 1, 6, 10, and 12 months after treatment

• naphthalene lung injury fails to induce restoration of this cell type