All Phenotypes Dph1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dph1⁺
wild type
MGI:2440051

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	\Dph1^tm1Bhr/\Dph1⁺	involves: 129/Sv * C57BL/6	MGI:3033453
ht2	\Dph1^tm2Bhr/\Dph1⁺	involves: 129/Sv * C57BL/6	MGI:3033458
cn3	\Dph1^tm2Bhr/\Dph1⁺ \Gt(ROSA)26Sor^tm1(DTA)Jpmb/\Gt(ROSA)26Sor⁺ \Mesp1^tm2(cre)Ysa/\Mesp1⁺	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:5659980
cn4	\Dph1^tm2Bhr/\Dph1⁺ \Gt(ROSA)26Sor^tm1(DTA)Jpmb/\Gt(ROSA)26Sor⁺ \H2az2^{Tg(Wnt1-cre)11Rth}/\H2az2⁺	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * CBA/J	MGI:5659976
cx5	\Dph1^tm2Bhr/\Dph1⁺ \Trp53^tm1Tyj/\Trp53⁺	involves: 129/Sv * C57BL/6	MGI:3033461

Allelic Composition	\Dph1^tm1Bhr/\Dph1⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1^tm1Bhr mutation (0 available); any Dph1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:88090 )

• 42% of heterozygotes develop tumors by 53-85 weeks of age

Allelic Composition	\Dph1^tm2Bhr/\Dph1⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1^tm2Bhr mutation (0 available); any Dph1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:88090 )

• 56% of heterozygotes develop tumors by 2 years of age

• mean occurance at 92 weeks

Allelic Composition	\Dph1^tm2Bhr/\Dph1⁺ \Gt(ROSA)26Sor^tm1(DTA)Jpmb/\Gt(ROSA)26Sor⁺ \Mesp1^tm2(cre)Ysa/\Mesp1⁺
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1^tm2Bhr mutation (0 available); any Dph1 mutation (25 available)
Gt(ROSA)26Sor^tm1(DTA)Jpmb mutation (2 available); any Gt(ROSA)26Sor mutation (1097 available)
Mesp1^tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:214744 )

• no embryos at E10.5

Allelic Composition	\Dph1^tm2Bhr/\Dph1⁺ \Gt(ROSA)26Sor^tm1(DTA)Jpmb/\Gt(ROSA)26Sor⁺ \H2az2^{Tg(Wnt1-cre)11Rth}/\H2az2⁺
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1^tm2Bhr mutation (0 available); any Dph1 mutation (25 available)
Gt(ROSA)26Sor^tm1(DTA)Jpmb mutation (2 available); any Gt(ROSA)26Sor mutation (1097 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

acephaly ( J:214744 )

• loss of head structures in E10.5 embryos

Allelic Composition	\Dph1^tm2Bhr/\Dph1⁺ \Trp53^tm1Tyj/\Trp53⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1^tm2Bhr mutation (0 available); any Dph1 mutation (25 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor latency ( J:88090 )

• latency of 52 weeks as opposed to 70 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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