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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dph1+
wild type
MGI:2440051
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Dph1tm1Bhr/Dph1+ involves: 129/Sv * C57BL/6 MGI:3033453
ht2
 		Dph1tm2Bhr/Dph1+ involves: 129/Sv * C57BL/6 MGI:3033458
cn3
 		Dph1tm2Bhr/Dph1+
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Mesp1tm2(cre)Ysa/Mesp1+ 		involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj MGI:5659980
cn4
 		Dph1tm2Bhr/Dph1+
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * CBA/J MGI:5659976
cx5
 		Dph1tm2Bhr/Dph1+
Trp53tm1Tyj/Trp53+ 		involves: 129/Sv * C57BL/6 MGI:3033461


Genotype
MGI:3033453
ht1
Allelic
Composition		 Dph1tm1Bhr/Dph1+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1tm1Bhr mutation (0 available); any Dph1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:88090 )
• 42% of heterozygotes develop tumors by 53-85 weeks of age




Genotype
MGI:3033458
ht2
Allelic
Composition		 Dph1tm2Bhr/Dph1+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1tm2Bhr mutation (0 available); any Dph1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:88090 )
• 56% of heterozygotes develop tumors by 2 years of age
• mean occurance at 92 weeks




Genotype
MGI:5659980
cn3
Allelic
Composition		 Dph1tm2Bhr/Dph1+
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Mesp1tm2(cre)Ysa/Mesp1+
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1tm2Bhr mutation (0 available); any Dph1 mutation (26 available)
Gt(ROSA)26Sortm1(DTA)Jpmb mutation (2 available); any Gt(ROSA)26Sor mutation (1083 available)
Mesp1tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5659976
cn4
Allelic
Composition		 Dph1tm2Bhr/Dph1+
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1tm2Bhr mutation (0 available); any Dph1 mutation (26 available)
Gt(ROSA)26Sortm1(DTA)Jpmb mutation (2 available); any Gt(ROSA)26Sor mutation (1083 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
acephaly ( J:214744 )
• loss of head structures in E10.5 embryos




Genotype
MGI:3033461
cx5
Allelic
Composition		 Dph1tm2Bhr/Dph1+
Trp53tm1Tyj/Trp53+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1tm2Bhr mutation (0 available); any Dph1 mutation (26 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (237 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor latency ( J:88090 )
• latency of 52 weeks as opposed to 70 weeks




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory