All Phenotypes Fst<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fst⁺
wild type
MGI:2439776

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Fst^tm1Zuk/Fst⁺	B6.129S7-Fst^tm1Zuk	MGI:5319775
ht2	Fst^{em1(IMPC)Wtsi}/Fst⁺	C57BL/6NCrl-Fst^{em1(IMPC)Wtsi}/Wtsi	MGI:7629001
ht3	Fst^tm1Zuk/Fst⁺	involves: 129S7/SvEvBrd	MGI:3814734
ht4	Fst^tm1Zuk/Fst⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:3814735
cx5	Fst^tm1Zuk/Fst⁺ Fstl3^tm1.1Sjl/Fstl3^tm1.1Sjl	B6.129-Fst^tm1Zuk Fstl3^tm1.1Sjl	MGI:5319774
cx6	Fst^tm1Zuk/Fst⁺ Mstn^tm1Sjl/Mstn^tm1Sjl	B6.129-Mstn^tm1Sjl Fst^tm1Zuk	MGI:5319776
cx7	Fst^tm1Zuk/Fst⁺ Mstn^tm1Sjl/Mstn⁺	B6.129-Mstn^tm1Sjl Fst^tm1Zuk	MGI:5319777
cx8	Fst^tm1Zuk/Fst⁺ Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl	involves: 129S7/SvEvBrd * C57BL/6	MGI:5546337

Allelic Composition	Fst^tm1Zuk/Fst⁺
Genetic Background	B6.129S7-Fst^tm1Zuk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fst^tm1Zuk mutation (2 available); any Fst mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal extensor digitorum longus morphology ( J:182827 )

• increase in the percentage of oxidative type I fibers

decreased quadriceps weight ( J:182827 )

abnormal gastrocnemius morphology ( J:182827 )

• increase in the number of oxidative type I fibers

decreased gastrocnemius weight ( J:182827 )

abnormal skeletal muscle fiber morphology ( J:182827 )

• increase in the proportion of smaller fibers that stain more darkly in hematoxylin and eosin stained sections corresponding to mixed glycolytic/oxidative type IIa fibers

• shift towards more oxidative fibers

• decrease in mean fiber diameter for each fiber type

decreased skeletal muscle weight ( J:182827 )

• about 15-20% lower than wild-type

• decreased triceps weight

abnormal pectoral muscle morphology ( J:182827 )

• decreased weight

abnormal muscle physiology ( J:182827 )

• lower twitch and tetanic force production

• but no change in specific force

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:182827 )

• impaired muscle regeneration and enhanced fibrosis in the gastrocnemius muscle following cardiotoxin-induced injury

limbs/digits/tail

abnormal extensor digitorum longus morphology ( J:182827 )

• increase in the percentage of oxidative type I fibers

decreased quadriceps weight ( J:182827 )

abnormal gastrocnemius morphology ( J:182827 )

• increase in the number of oxidative type I fibers

decreased gastrocnemius weight ( J:182827 )

Allelic Composition	Fst^{em1(IMPC)Wtsi}/Fst⁺
Genetic Background	C57BL/6NCrl-Fst^{em1(IMPC)Wtsi}/Wtsi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fst^{em1(IMPC)Wtsi} mutation (1 available); any Fst mutation (19 available)

Data Sources

IMPC Data for Fst

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - HMGU

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - HMGU

skeleton

decreased bone mineral density ( J:211773 )

IMPC - HMGU

vision/eye

abnormal vitreous body morphology ( J:211773 )

IMPC - HMGU

persistence of hyaloid vascular system ( J:211773 )

IMPC - HMGU

Allelic Composition	Fst^tm1Zuk/Fst⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fst^tm1Zuk mutation (2 available); any Fst mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal rib development ( J:23925 )

• in 26.6% (4 of 15) heterozygotes, development of the thirteenth pair of ribs is limited; not oberved in wild-type controls

• Background Sensitivity: a higher percentage of heterozygotes show limited formation of the thirteenth rib pair on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (26.6% vs 17%, respectively)

decreased lumbar vertebrae number ( J:23925 )

• 86.6% (13 of 15) heterozygotes have five lumbar vertebrae instead of six found in wild-type controls

• Background Sensitivity: a higher percentage of heterozygotes show five lumbar vertebrae on an inbred 129/SvEv background than on a hybrid 129/SvEv x C57BL/6 background (86.6% vs 60%, respectively)

Allelic Composition	Fst^tm1Zuk/Fst⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fst^tm1Zuk mutation (2 available); any Fst mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal rib development ( J:23925 )

• in 17% (6 of 35) heterozygotes, development of the thirteenth pair of ribs is limited; not oberved in wild-type controls

decreased lumbar vertebrae number ( J:23925 )

• 60% (21 of 35) heterozygotes have five lumbar vertebrae instead of six; only 2 of 15 wild-type controls show this defect

Allelic Composition	Fst^tm1Zuk/Fst⁺ Fstl3^tm1.1Sjl/Fstl3^tm1.1Sjl
Genetic Background	B6.129-Fst^tm1Zuk Fstl3^tm1.1Sjl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fstl3^tm1.1Sjl mutation (0 available); any Fstl3 mutation (20 available)
Fst^tm1Zuk mutation (2 available); any Fst mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

decreased skeletal muscle weight ( J:182827 )

• similar to mice heterozygous for Fst^tm1Zuk alone

Allelic Composition	Fst^tm1Zuk/Fst⁺ Mstn^tm1Sjl/Mstn^tm1Sjl
Genetic Background	B6.129-Mstn^tm1Sjl Fst^tm1Zuk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fst^tm1Zuk mutation (2 available); any Fst mutation (19 available)
Mstn^tm1Sjl mutation (2 available); any Mstn mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

decreased skeletal muscle weight ( J:182827 )

• relative to mice homoozygous for Mstn^tm1Sjl alone

Allelic Composition	Fst^tm1Zuk/Fst⁺ Mstn^tm1Sjl/Mstn⁺
Genetic Background	B6.129-Mstn^tm1Sjl Fst^tm1Zuk

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

decreased skeletal muscle weight ( J:182827 )

• relative to mice heterozygous for Mstn^tm1Sjl alone

growth/size/body

decreased body weight ( J:182827 )

• relative to mice heterozygous for Mstn^tm1Sjl alone

Allelic Composition	Fst^tm1Zuk/Fst⁺ Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fst^tm1Zuk mutation (2 available); any Fst mutation (19 available)
Wfikkn1^tm1.1Sjl mutation (0 available); any Wfikkn1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Axial skeleton patterning defects in Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl, Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Fst^tm1Zuk/Fst^tm1Zuk, Gdf11^tm1Sjl/Gdf11⁺ and Gdf11^tm1Sjl/Gdf11^tm1Sjl mice.

skeleton

abnormal cervical rib ( J:201148 )

• cervical ribs are seen on one or both sides in most mice

decreased rib number ( J:201148 )

• over 90% of mice are missing both 13th ribs

increased rib number ( J:201148 )

• cervical ribs are seen on one or both sides in most mice

decreased thoracic vertebrae number ( J:201148 )

• most mice have 12 thoracic vertebrae

increased lumbar vertebrae number ( J:201148 )

• 25% of mice have 6/7 lumbar vertebrae

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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