Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sfn+ wild type MGI:2439556 |
||||||||||||||||||||||||
| Summary |
5 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Repeated hair loss in SfnEr/Sfn+ mice
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• increased mortality starting at about the time hair loss starts and continuing through weaning and a little after
• mice surviving the post weaning period are fertile and live normal lifespans
|
|
• starting about the same time as hair loss
|
|
• 67% frequency in mice older than 6 months
• begin as small sessile or pedunculated papillomas, then most enlarge, and many develop horns
• no evidence of virus particles
|
|
• 67% frequency in mice older than 6 months
• squamous cell carcinomas in the fleshy base of large cutaneous horns
• no evidence of virus particles
|
|
• first coat lost by 3 weeks then quickly replaced and lost again
(J:6200)
• hair loss begins around eyes and nose
(J:6200)
• normal until around 13 days when hair loss begins
(J:29020)
|
|
• 67% frequency in mice older than 6 months
• begin as small sessile or pedunculated papillomas, then most enlarge, and many develop horns
• no evidence of virus particles
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• eyelids, ears, snout and digit/tail tips
|
|
• eyelids, ears, snout and digit/tail tips
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• severe intraoral adhesions prevent opening of mouth at E17
|
|
• seen at E17
|
|
• affected pups show forepaw and hindpaw syndactyly
|
|
• at E17
|
|
• seen at E17
|
|
• fused esophagus is found at E17
|
|
• at E17, affected pups have smooth skin
|
|
• epidermis is hyperproliferative
|
|
• areas of keratinization are frequently detected within and sometimes on surface of expanded suprabasal layers
|
|
• mutants have thickened epithelium resulting from expanded stratum spinosum; clearly defined stratum granulosum and stratum corneum do not form toward epidermal surface
|
|
• severe intraoral adhesions prevent opening of mouth at E17
|
|
• seen at E17
|
|
• at E17, partial fusion of hindlimbs and tail to body wall is observed
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• despite Mendelian numbers during embryonic development, only 1 mouse was obtained postnatally
|
|
• in several areas, pronounced in the eyelids, ears, snout, digit/tail tips, chin and two dorsal stripes
|
|
• breaks in the cornified layer in dorsal stripes
• however, most regions exhibit normal cornified layers
|
|
• in the one recovered mouse
|
|
• in the one recovered mouse
|
|
• in several areas, pronounced in the eyelids, ears, snout, digit/tail tips, chin and two dorsal stripes
|
|
• in the one recovered mouse
|
|
• in the one recovered mouse
|
|
• in the one recovered mouse
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 03/25/2025 MGI 6.24 |
|
|
|
||
