Analysis Tools|
Allele Symbol Allele Name Allele ID |
Fzd2+ wild type MGI:2439471 |
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| Summary |
11 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all die by E11
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• starting at E9.5
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• starting at E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• more than 50% die postnatally
• survivors are viable and fertile
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• 50% of embryos (n=22) display cardiac defects
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• DORV in combination with a ventricular septal defect is occasionally seen
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| N |
• Background Sensitivity: no palate closure defects are detected in mice on a mixed strain background including 129 and C57BL/6; however, palate closure defects are seen in mice on a mixed strain background including 129, C57BL/6 and LPT/LeJ
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 83% of embryos (n=12) display cardiac defects
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• most defects are VSDs
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 92% of embryos (n=12) display cardiac defects
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• most defects are VSDs
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• in 14% of embryos (n=14)
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• in 14% of embryos (n=14)
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• in 14% of embryos (n=14)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 100% of embryos (n=10) display cardiac defects
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• most defects are VSDs
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• in 11% of embryos (n=9)
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• in 11% of embryos (n=9)
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• in 11% of embryos (n=9)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 37% of embryos (n=18) display cardiac defects
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• most defects are VSDs
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• in 53% of embryos (n=17)
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• in 53% of embryos (n=17)
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• in 53% of embryos (n=17)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: seen in 15% of embryos (n=13) in mice on a mixed strain background containing 129, C57BL/6 and LPT/LeJ; however, cleft palate is not seen in mice on mixed strain background including 129 and C57BL/6 but not LPT/LeJ
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• Background Sensitivity: seen in 15% of embryos (n=13) in mice on a mixed strain background containing 129, C57BL/6 and LPT/LeJ; however, cleft palate is not seen in mice on mixed strain background including 129 and C57BL/6 but not LPT/LeJ
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• Background Sensitivity: seen in 15% of embryos (n=13) in mice on a mixed strain background containing 129, C57BL/6 and LPT/LeJ; however, cleft palate is not seen in mice on mixed strain background including 129 and C57BL/6 but not LPT/LeJ
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% of embryos (n=6) display cardiac defects compared to 0% of embryos heterozygous for either mutation alone
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• most defects are VSDs
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in 1 of 8 mice
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• in 2 of 208 mice
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• in 2 of 208 mice
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• in 2 of 208 mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in 4 of 7 mice, more common in the rostral neural tube
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• muscular and/or membranous in mice with neural tube defects
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• in 4 of 7 mice, more common in the rostral neural tube
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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