Analysis Tools|
Allele Symbol Allele Name Allele ID |
Fzd2+ wild type MGI:2439471 |
||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
11 genotypes
|
|
|
Data Sources
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• all die by E11
|
|
• starting at E9.5
|
|
• starting at E9.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• more than 50% die postnatally
• survivors are viable and fertile
|
|
• 50% of embryos (n=22) display cardiac defects
|
|
• DORV in combination with a ventricular septal defect is occasionally seen
|
| N |
• Background Sensitivity: no palate closure defects are detected in mice on a mixed strain background including 129 and C57BL/6; however, palate closure defects are seen in mice on a mixed strain background including 129, C57BL/6 and LPT/LeJ
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 83% of embryos (n=12) display cardiac defects
|
|
• most defects are VSDs
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 92% of embryos (n=12) display cardiac defects
|
|
• most defects are VSDs
|
|
• in 14% of embryos (n=14)
|
|
• in 14% of embryos (n=14)
|
|
• in 14% of embryos (n=14)
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 100% of embryos (n=10) display cardiac defects
|
|
• most defects are VSDs
|
|
• in 11% of embryos (n=9)
|
|
• in 11% of embryos (n=9)
|
|
• in 11% of embryos (n=9)
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 37% of embryos (n=18) display cardiac defects
|
|
• most defects are VSDs
|
|
• in 53% of embryos (n=17)
|
|
• in 53% of embryos (n=17)
|
|
• in 53% of embryos (n=17)
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• Background Sensitivity: seen in 15% of embryos (n=13) in mice on a mixed strain background containing 129, C57BL/6 and LPT/LeJ; however, cleft palate is not seen in mice on mixed strain background including 129 and C57BL/6 but not LPT/LeJ
|
|
• Background Sensitivity: seen in 15% of embryos (n=13) in mice on a mixed strain background containing 129, C57BL/6 and LPT/LeJ; however, cleft palate is not seen in mice on mixed strain background including 129 and C57BL/6 but not LPT/LeJ
|
|
• Background Sensitivity: seen in 15% of embryos (n=13) in mice on a mixed strain background containing 129, C57BL/6 and LPT/LeJ; however, cleft palate is not seen in mice on mixed strain background including 129 and C57BL/6 but not LPT/LeJ
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 50% of embryos (n=6) display cardiac defects compared to 0% of embryos heterozygous for either mutation alone
|
|
• most defects are VSDs
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• in 1 of 8 mice
|
|
• in 2 of 208 mice
|
|
• in 2 of 208 mice
|
|
• in 2 of 208 mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• in 4 of 7 mice, more common in the rostral neural tube
|
|
• muscular and/or membranous in mice with neural tube defects
|
|
• in 4 of 7 mice, more common in the rostral neural tube
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 01/20/2026 MGI 6.24 |
|
|
|
||
