All Phenotypes Akt1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Akt1⁺
wild type
MGI:2439015

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Akt1^tm1.1Mjl/Akt1⁺	chimera involves: 129S6/SvEvTac * C57BL/6	MGI:6460379
cn2	Akt1^tm1Mjl/Akt1⁺ Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:6460345
cx3	Akt1^tm1Mbb/Akt1⁺ Flt1^tm1Jrt/Flt1⁺	involves: 129P2/OlaHsd	MGI:4844292
cx4	Akt1^tm1Hem/Akt1⁺ Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem	involves: 129P2/OlaHsd * C57BL/6	MGI:3691596
cx5	Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ	MGI:3848163
cx6	Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg Pten^tm1Ppp/Pten⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ	MGI:3848161
cx7	Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg Akt3^tm1Nhy/Akt3^tm1Nhy	involves: 129/Sv * C57BL/6 * DBA/1LacJ	MGI:3848164

Allelic Composition	Akt1^tm1.1Mjl/Akt1⁺
Genetic Background	chimera involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1.1Mjl mutation (0 available); any Akt1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:293971 )

• vascular malformations are seen in lymph nodes, adipose tissue, spleen, and/or other locations

• visible vascular malformations appear as dark, blood-filled, often multi-lobulated cystic masses

• vascular malformations are characterized as venous-capillary mixed-type malformations with ectatic channels and often containing a lymphatic component and no atypia

• numerous, variably-sized, thin-walled ectatic vessels, often separated by increased stroma are seen in these lesions

• vascular malformations in adipose tissue are comprised of multiple thin-walled vessels

endocrine/exocrine glands

biliary cyst ( J:293971 )

• biliary cysts are the most frequent type of cyst

dilated bile duct ( J:293971 )

• biliary ductule ectasia is seen in some mice

abnormal mammary gland duct morphology ( J:293971 )

• some mice exhibit mammary ductal ectasia

• 4 mice show unusual polypoid projections into mammary ducts that appear to be inversions of disorganized fatty and stromal tissue

mammary gland alveolar hyperplasia ( J:293971 )

• some mice exhibit alveolar hyperplasia

abnormal mammary gland stroma morphology ( J:293971 )

• some mice exhibit expansion of the supporting stroma

mammary gland hyperplasia ( J:293971 )

• some mice exhibit overgrowth of breast tissue

integument

abnormal mammary gland duct morphology ( J:293971 )

• some mice exhibit mammary ductal ectasia

• 4 mice show unusual polypoid projections into mammary ducts that appear to be inversions of disorganized fatty and stromal tissue

mammary gland alveolar hyperplasia ( J:293971 )

• some mice exhibit alveolar hyperplasia

abnormal mammary gland stroma morphology ( J:293971 )

• some mice exhibit expansion of the supporting stroma

mammary gland hyperplasia ( J:293971 )

• some mice exhibit overgrowth of breast tissue

epidermal hyperplasia ( J:293971 )

• one mice shows an area of epidermal hyperplasia similar to epidermal nevi

liver/biliary system

biliary cyst ( J:293971 )

• biliary cysts are the most frequent type of cyst

dilated bile duct ( J:293971 )

• biliary ductule ectasia is seen in some mice

growth/size/body

biliary cyst ( J:293971 )

• biliary cysts are the most frequent type of cyst

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Proteus syndrome		DOID:13482	OMIM:176920	J:293971

Allelic Composition	Akt1^tm1Mjl/Akt1⁺ Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Mjl mutation (0 available); any Akt1 mutation (37 available)
Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} mutation (3 available); any Gt(ROSA)26Sor mutation (1062 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:293971 )

• vascular malformations are seen in lymph nodes, spleen, and/or other locations in mice from pregnant females treated with tamoxifen at E5.5

• visible vascular malformations appear as dark, blood-filled, often multi-lobulated cystic masses

• vascular malformations are characterized as venous-capillary mixed-type malformations with ectatic channels and often containing a lymphatic component and no atypia

• numerous, variably-sized, thin-walled ectatic vessels, often separated by increased stroma are seen in these lesion

endocrine/exocrine glands

biliary cyst ( J:293971 )

• biliary cysts are the most frequent type of cyst seen in mice from pregnant females treated with tamoxifen at E5.5

dilated bile duct ( J:293971 )

• biliary ductule ectasia is seen in some mice treated with tamoxifen at E5.5

abnormal mammary gland duct morphology ( J:293971 )

• mammary changes in mice treated with tamoxifen at E5.5 include ductal ectasia

mammary gland alveolar hyperplasia ( J:293971 )

• seen in some mice treated with tamoxifen at E5.5

abnormal mammary gland stroma morphology ( J:293971 )

• mammary changes in mice treated with tamoxifen at E5.5 include expansion of the supporting stroma

mammary gland hyperplasia ( J:293971 )

• overgrowth of breast tissue is seen in mice from pregnant females treated with tamoxifen at E5.5

integument

abnormal mammary gland duct morphology ( J:293971 )

• mammary changes in mice treated with tamoxifen at E5.5 include ductal ectasia

mammary gland alveolar hyperplasia ( J:293971 )

• seen in some mice treated with tamoxifen at E5.5

abnormal mammary gland stroma morphology ( J:293971 )

• mammary changes in mice treated with tamoxifen at E5.5 include expansion of the supporting stroma

mammary gland hyperplasia ( J:293971 )

• overgrowth of breast tissue is seen in mice from pregnant females treated with tamoxifen at E5.5

liver/biliary system

biliary cyst ( J:293971 )

• biliary cysts are the most frequent type of cyst seen in mice from pregnant females treated with tamoxifen at E5.5

dilated bile duct ( J:293971 )

• biliary ductule ectasia is seen in some mice treated with tamoxifen at E5.5

growth/size/body

biliary cyst ( J:293971 )

• biliary cysts are the most frequent type of cyst seen in mice from pregnant females treated with tamoxifen at E5.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Proteus syndrome		DOID:13482	OMIM:176920	J:293971

Allelic Composition	Akt1^tm1Mbb/Akt1⁺ Flt1^tm1Jrt/Flt1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Mbb mutation (1 available); any Akt1 mutation (37 available)
Flt1^tm1Jrt mutation (1 available); any Flt1 mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:151369 )

N	• following hind limb ischemia, mice exhibit normal blood flow and capillary density

Allelic Composition	Akt1^tm1Hem/Akt1⁺ Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Hem mutation (0 available); any Akt1 mutation (37 available)
Akt2^tm1Hem mutation (0 available); any Akt2 mutation (54 available)
Akt3^tm1Hem mutation (0 available); any Akt3 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:114675 )

• viable and fertile and showed no obvious defects except for a severe growth deficiency

decreased body weight ( J:114675 )

• body weight at the age of 12 weeks reduced around 40% of wild-type

Allelic Composition	Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Nhy mutation (0 available); any Akt1 mutation (37 available)
Akt2^tm1Rsg mutation (0 available); any Akt2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:149156 )

• the few insulin+ beta cells exhibit reduced insulin production compared to in wild-type mice

• ex-vivo, glucose-stimulated beta-cells produce and secrete less insulin than similarly treated wild-type cells

hyperglycemia ( J:149156 )

• as early as 1 month after birth, mice exhibit a 2- to 3-fold increase in serum glucose level compared with wild-type mice whether fed or fasted

• increased glucose levels cannot be lowered by injection of insulin as in wild-type mice

• however, mice treated with a leptin-expressing adenovirus exhibit normal glucose levels

increased circulating insulin level ( J:149156 )

• mice exhibit increased serum insulin levels compared with wild-type mice that are 3-fold lower than in Akt2^tm1Rsg homozygotes

• however, injection of glucose does not increase serum insulin levels

• however, mice treated with a leptin-expressing adenovirus exhibit normal insulin levels

decreased circulating leptin level ( J:149156 )

impaired glucose tolerance ( J:149156 )

• mice exhibit a diabetic response to glucose challenge

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:149156 )

• fewer insulin+ beta-cells are detected in pancreatic islet cells compared to in wild-type mice or Akt2^tm1Rsg homozygotes

enlarged pancreatic islets ( J:149156 )

• compared to in Akt2^tm1Rsg homozygotes

decreased insulin secretion ( J:149156 )

• the few insulin+ beta cells exhibit reduced insulin production compared to in wild-type mice

• ex-vivo, glucose-stimulated beta-cells produce and secrete less insulin than similarly treated wild-type cells

adipose tissue

decreased white adipose tissue amount ( J:149156 )

decreased percent body fat/body weight ( J:149156 )

Allelic Composition	Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg Pten^tm1Ppp/Pten⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:149156 )

• following glucose injection, mice exhibit a greater increase in serum insulin levels compared with similarly treated wild-type mice

impaired glucose tolerance ( J:149156 )

• mice exhibit impaired glucose tolerance that is not as severe as in Akt1^tm1Nhy/Akt1^tm1Nhy Akt2^tm1Rsg/Akt2^tm1Rsg mice

• however, mice exhibit normal glucose serum levels under normal conditions

endocrine/exocrine glands

enlarged pancreatic islets ( J:149156 )

• compared to in Akt2^tm1Rsg homozygotes

Allelic Composition	Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg Akt3^tm1Nhy/Akt3^tm1Nhy
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/1LacJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:149156 )

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