All Phenotypes Agtr1a<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Agtr1a⁺
wild type
MGI:2438993

Summary

2 genotypes

Allelic Composition	Agtr1a^tm1Unc/Agtr1a⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1a^tm1Unc mutation (1 available); any Agtr1a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

• pressure responses to angiotensin II administration are short lived compared to wild-type

• arterial pressure measured by carotid cannula is reduced by 17 mmHg

• systolic blood pressure measured by tail cuff sphygmomanometer is reduced by 12 mmHg

Allelic Composition	Agtr1a^tm1Afu/Agtr1a⁺
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1a^tm1Afu mutation (1 available); any Agtr1a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

• heterozygotes display a 10 mm Hg reduction in systolic blood pressure relative to wild-type mice

hypotension ( J:28041 )

• heterozygotes exhibit chronic hypotension, with a significant decline in both the systolic and diastolic blood pressure relative to wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:28041 )

N	• heterozygotes show no significant differences in renin mRNA levels in the kidney or in plasma renin activity relative to wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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