All Phenotypes Opn4<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Opn4⁺
wild type
MGI:2438687

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Opn4^tm4(DTA)Saha/Opn4⁺	involves: 129 * C57BL/6	MGI:3797741
cn2	Opn4^{tm2.1(cre/ERT2)Saha}/Opn4⁺ Pou4f2^tm2.1Nat/Pou4f2⁺	involves: 129 * C57BL/6	MGI:5285911
cn3	Dscam^tm1Pfu/Dscam^tm1Pfu Opn4^tm1(cre)Sapa/Opn4⁺	involves: 129 * C57BL/6	MGI:5305038
cn4	Opn4^{tm1.1(cre)Saha}/Opn4⁺ Pou4f2^tm2.1Nat/Pou4f2⁺	involves: 129 * C57BL/6	MGI:5285910
cn5	Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺ Opn4^tm1(cre)Sapa/Opn4⁺	involves: 129S * C57BL/6	MGI:3803116
cn6	Opn4^{tm1.1(cre)Saha}/Opn4⁺ Pou4f2^tm4(DTA)Whk/Pou4f2⁺ Tg(CAG-Bgeo/ALPP)1Lbe/0	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5285913
cn7	Opn4^{tm1.1(cre)Saha}/Opn4⁺ Pou4f2^tm4(DTA)Whk/Pou4f2⁺	involves: 129S/SvEv * C57BL/6	MGI:5285914

Allelic Composition	Opn4^tm4(DTA)Saha/Opn4⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4^tm4(DTA)Saha mutation (0 available); any Opn4 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

impaired pupillary reflex ( J:134780 )

• papillary light reflex is absent when exposed to light bright enough to cause 50% constriction in wild-type controls

• 3 of 9 mice have decreased papillary light reflex in response to high intensity light

abnormal retina ganglion cell morphology ( J:134780 )

• only 3.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls

• the degree of ablation for melanopsin-containing retinal ganglion cells increases with age until they are virtually absent at one year of age

behavior/neurological

impaired pupillary reflex ( J:134780 )

• papillary light reflex is absent when exposed to light bright enough to cause 50% constriction in wild-type controls

• 3 of 9 mice have decreased papillary light reflex in response to high intensity light

nervous system

abnormal retina ganglion cell morphology ( J:134780 )

• only 3.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls

• the degree of ablation for melanopsin-containing retinal ganglion cells increases with age until they are virtually absent at one year of age

Allelic Composition	Opn4^{tm2.1(cre/ERT2)Saha}/Opn4⁺ Pou4f2^tm2.1Nat/Pou4f2⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4^{tm2.1(cre/ERT2)Saha} mutation (1 available); any Opn4 mutation (33 available)
Pou4f2^tm2.1Nat mutation (1 available); any Pou4f2 mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal suprachiasmatic nucleus morphology ( J:174940 )

• with injection of 500 ug tamoxifen intraperitoneally at P14, medial regions of the suprachiasmatic nucleus are not innervated at all

abnormal innervation ( J:174940 )

• with injection of 500 ug tamoxifen intraperitoneally at P14, suprachiasmatic nucleus (SCN) is sparsely innervated by Pou4f2-positive ipRGCs (intrinsically photosensitive retinal ganglion cells)

Allelic Composition	Dscam^tm1Pfu/Dscam^tm1Pfu Opn4^tm1(cre)Sapa/Opn4⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dscam^tm1Pfu mutation (1 available); any Dscam mutation (106 available)
Opn4^tm1(cre)Sapa mutation (0 available); any Opn4 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina ganglion cell morphology ( J:179393 )

• fasiculation and spacing phenotype in melanopsin positive RGCs

nervous system

abnormal axon fasciculation ( J:179393 )

• fasiculation and spacing phenotype in melanopsin positive RGCs

abnormal retina ganglion cell morphology ( J:179393 )

• fasiculation and spacing phenotype in melanopsin positive RGCs

cellular

abnormal axon fasciculation ( J:179393 )

• fasiculation and spacing phenotype in melanopsin positive RGCs

Allelic Composition	Opn4^{tm1.1(cre)Saha}/Opn4⁺ Pou4f2^tm2.1Nat/Pou4f2⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4^{tm1.1(cre)Saha} mutation (0 available); any Opn4 mutation (33 available)
Pou4f2^tm2.1Nat mutation (1 available); any Pou4f2 mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal suprachiasmatic nucleus morphology ( J:174940 )

• medial regions of the suprachiasmatic nucleus are not innervated at all

abnormal innervation ( J:174940 )

• the suprachiasmatic nucleus (SCN) is sparsely innervated by Pou4f2-positive ipRGCs (intrinsically photosensitive retinal ganglion cells)

Allelic Composition	Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺ Opn4^tm1(cre)Sapa/Opn4⁺
Genetic Background	involves: 129S * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(HBEGF)Awai} mutation (4 available); any Gt(ROSA)26Sor mutation (1098 available)
Opn4^tm1(cre)Sapa mutation (0 available); any Opn4 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

impaired pupillary reflex ( J:137151 )

• following treatment with diphtheria toxin, light pupilary reflex is lost

decreased retina ganglion cell number ( J:137151 )

• following treatment with diphtheria toxin, 90% of melanopsin retinal ganglion cells are ablated

nervous system

abnormal suprachiasmatic nucleus morphology ( J:137151 )

• following treatment with diphtheria toxin, projections into the suprachiasmatic nucleus are reduced compared to in wild-type mice

decreased retina ganglion cell number ( J:137151 )

• following treatment with diphtheria toxin, 90% of melanopsin retinal ganglion cells are ablated

behavior/neurological

behavior/neurological phenotype ( J:137151 )

N	• despite ablation of melanopsin retinal ganglion cells following treatment with diphtheria toxin, mice exhibit normal image-forming visual responses

impaired pupillary reflex ( J:137151 )

• following treatment with diphtheria toxin, light pupilary reflex is lost

abnormal circardian behavior entrainment ( J:137151 )

• following treatment with diphtheria toxin, mice lose their ability to photo-entrain their circadian rhythm and mice maintain equal activity during light and dark phases unlike in wild-type mice

Allelic Composition	Opn4^{tm1.1(cre)Saha}/Opn4⁺ Pou4f2^tm4(DTA)Whk/Pou4f2⁺ Tg(CAG-Bgeo/ALPP)1Lbe/0
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4^{tm1.1(cre)Saha} mutation (0 available); any Opn4 mutation (33 available)
Pou4f2^tm4(DTA)Whk mutation (1 available); any Pou4f2 mutation (7 available)
Tg(CAG-Bgeo/ALPP)1Lbe mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olivary pretectal nucleus morphology ( J:174940 )

• and olivary pretectal nucleus (OPN) projections are eliminated, compared to controls

abnormal innervation ( J:174940 )

• innervation of the intergeniculate leaflet (IGL) is markedly reduced

decreased retina ganglion cell number ( J:174940 )

• all non-M1 retinal ganglion cells are ablated in the retinas, with only about 200 Pou4f2-negative cells detected (200/2000); these remaining fibers innervated the SCN to the same extent as control Pou4f2^tm2.1Nat/+ Opn4^{tm1.1(cre)Saha/+} animals

vision/eye

decreased retina ganglion cell number ( J:174940 )

Allelic Composition	Opn4^{tm1.1(cre)Saha}/Opn4⁺ Pou4f2^tm4(DTA)Whk/Pou4f2⁺
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:174940 )

N	• mutants are able to photoentrain (their circadian phase) like controls; also, activity

impaired pupillary reflex ( J:174940 )

• the papillary light reflex (PLR) is significantly attenuated at high and low light intensities in the middle of the day (zeitgerber time 8, ZT8); in the middle of the night (ZT20), mice show no PLR

abnormal circadian behavior period ( J:174940 )

• animals show a minor deficit in period lengthening under constant light conditions

nervous system

decreased retina ganglion cell number ( J:174940 )

• only 200 M1 (Pou4f2-negative) ipRGCs (intrinsically photosensitive retinal ganglion cells) are detected in the retinas

vision/eye

vision/eye phenotype ( J:174940 )

N	• visual acuity is comparable to wild-type animals

impaired pupillary reflex ( J:174940 )

decreased retina ganglion cell number ( J:174940 )

• only 200 M1 (Pou4f2-negative) ipRGCs (intrinsically photosensitive retinal ganglion cells) are detected in the retinas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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