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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spry1+
wild type
MGI:2438068
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gdnftm1(cre/ERT2)Cos/Gdnf+
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Spry1tm1.1Jdli/Spry1+ 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J MGI:5553081
cx2
 		Gdnftm1Bbd/Gdnf+
Spry1tm1.1Jdli/Spry1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5553082
cx3
 		Itga8tm1Lfr/Itga8tm1Lfr
Spry1tm1.1Jdli/Spry1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3715487


Genotype
MGI:5553081
cn1
Allelic
Composition		 Gdnftm1(cre/ERT2)Cos/Gdnf+
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Spry1tm1.1Jdli/Spry1+
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnftm1(cre/ERT2)Cos mutation (1 available); any Gdnf mutation (20 available)
Gt(ROSA)26Sortm1(DTA)Jpmb mutation (2 available); any Gt(ROSA)26Sor mutation (1062 available)
Spry1tm1.1Jdli mutation (0 available); any Spry1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
small kidney ( J:206853 )
• with tamoxifen treatment at E12.5, presence of a single copy of Spry1 only marginally improves the hypoplasia observed at E19.5




Genotype
MGI:5553082
cx2
Allelic
Composition		 Gdnftm1Bbd/Gdnf+
Spry1tm1.1Jdli/Spry1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnftm1Bbd mutation (0 available); any Gdnf mutation (20 available)
Spry1tm1.1Jdli mutation (0 available); any Spry1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:206853 )
N
• at E19.5, double heterozygous animals show full rescue of the renal hypoplasia seen in Gdnftm1Bbd heterozygotes




Genotype
MGI:3715487
cx3
Allelic
Composition		 Itga8tm1Lfr/Itga8tm1Lfr
Spry1tm1.1Jdli/Spry1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga8tm1Lfr mutation (2 available); any Itga8 mutation (75 available)
Spry1tm1.1Jdli mutation (0 available); any Spry1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
absent kidney ( J:122519 )
• 25% kidney agenesis incidence




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory