Gdnf^{tm1(cre/ERT2)Cos}
Targeted Allele Detail

Summary

• Symbol: Gdnf^{tm1(cre/ERT2)Cos}
• Name: glial cell line derived neurotrophic factor; targeted mutation 1, Frank Costantini
• MGI ID: MGI:5553062
• Synonyms: Gdnf^CreERT2
• Gene: Gdnf Location: Chr15:7840327-7867056 bp, + strand Genetic Position: Chr15, 3.8 cM
• Alliance: Gdnf^{tm1(cre/ERT2)Cos} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206853
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gdnf^{tm1(cre/ERT2)Cos} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gdnf (MGI:107430)

• Mutation details: A targeting vector was designed to insert (from 5' to 3') a glial cell line derived neurotrophic factor (Gdnf) cDNA, an internal ribosomal entry sequence 2 (IRES2), cre/ERT2 coding sequence, an SV40 polyA sequence, and a neomycin selection cassette into exon 2 of the Gdnf gene (J:206853)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gdnf (mouse) Summary of all recombinase alleles driven by Gdnf. Alliance mouse Gdnf gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gdnf Mutation: 18 strains or lines available

References

• Original: J:206853 Cebrian C, et al., The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment. Cell Rep. 2014 Apr 10;7(1):127-37
• All: 4 reference(s)