About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dok2+
wild type
MGI:2437425
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Dok2tm1Ppp/Dok2+ 129S1/Sv-Dok2tm1Ppp MGI:4443012
cx2
 		Dok2tm1Ppp/Dok2+
Tg(Tec-BCR/ABL1)5Hhi/0 		involves: 129S1/Sv MGI:3574546


Genotype
MGI:4443012
ht1
Allelic
Composition		 Dok2tm1Ppp/Dok2+
Genetic
Background		 129S1/Sv-Dok2tm1Ppp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok2tm1Ppp mutation (0 available); any Dok2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:158011 )
• at 15 to 19 months, 4 of 12 mice develop lung tumors unlike wild-type mice

respiratory system
increased lung tumor incidence ( J:158011 )
• at 15 to 19 months, 4 of 12 mice develop lung tumors unlike wild-type mice




Genotype
MGI:3574546
cx2
Allelic
Composition		 Dok2tm1Ppp/Dok2+
Tg(Tec-BCR/ABL1)5Hhi/0
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok2tm1Ppp mutation (0 available); any Dok2 mutation (16 available)
Tg(Tec-BCR/ABL1)5Hhi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:95334 )
• loss of Dok2 shortened lifespan to about 283 days from about 321 days in mice that are hemizygous for Tg(BCR/ABL1)5Hhi and wild-type for Dok2

neoplasm
increased leukemia incidence ( J:95334 )
• inactivation of Dok2 accelerated the onset of the chronic phase and the fatal blastic phase
• acceleration was not as severe as in homozygous null mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
 J:95334




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory