All Phenotypes Prss8<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prss8⁺
wild type
MGI:2437036

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Prss8^{tm1b(EUCOMM)Hmgu}/Prss8⁺	C57BL/6N-Prss8^{tm1b(EUCOMM)Hmgu}/J	MGI:6263257
cx2	Prss8^fr/Prss8⁺ Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg}	involves: 129P2/OlaHsd * DBA	MGI:5440274
cx3	Prss8^fr/Prss8⁺ Spint1^tm1Bug/Spint1^tm1Bug	involves: 129S6/SvEvTac * DBA	MGI:5440272
cx4	Oat^rhg/Prss8^fr	involves: AKR/J * C57BL/6JEi * FS/EiJ	MGI:6162250

Allelic Composition	Prss8^{tm1b(EUCOMM)Hmgu}/Prss8⁺
Genetic Background	C57BL/6N-Prss8^{tm1b(EUCOMM)Hmgu}/J
Cell Lines	HEPD0723_1_C12

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Prss8 mutation (23 available)

Data Sources

IMPC Data for Prss8

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased thigmotaxis ( J:211773 )

IMPC - JAX

increased grip strength ( J:211773 )

IMPC - JAX

hematopoietic system

decreased mean corpuscular hemoglobin concentration ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

IMPC - JAX

vision/eye

cataract ( J:211773 )

IMPC - JAX

Allelic Composition	Prss8^fr/Prss8⁺ Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg}
Genetic Background	involves: 129P2/OlaHsd * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^fr mutation (13 available); any Prss8 mutation (23 available)
Spint2^{Gt(KST272)Byg} mutation (0 available); any Spint2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:188121 )

• no embryos are detected at E9.5-E11.5

Allelic Composition	Prss8^fr/Prss8⁺ Spint1^tm1Bug/Spint1^tm1Bug
Genetic Background	involves: 129S6/SvEvTac * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^fr mutation (13 available); any Prss8 mutation (23 available)
Spint1^tm1Bug mutation (0 available); any Spint1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:188121 )

embryo

spina bifida ( J:188121 )

abnormal placenta morphology ( J:188121 )

• placental differentiation defects

limbs/digits/tail

curly tail ( J:188121 )

nervous system

spina bifida ( J:188121 )

exencephaly ( J:188121 )

Allelic Composition	Oat^rhg/Prss8^fr
Genetic Background	involves: AKR/J * C57BL/6JEi * FS/EiJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oat^rhg mutation (1 available); any Oat mutation (20 available)
Prss8^fr mutation (13 available); any Prss8 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:213842 )

• double heterozygotes complement, having normal vibrissae, fur, and body size

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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