All Phenotypes Rybp<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rybp⁺
wild type
MGI:2436933

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	\Rybp^em1(IMPC)Bay/\Rybp⁺	C57BL/6N-Rybp^em1(IMPC)Bay/Bay	MGI:7768416
ht2	\Rybp^tm1Nisa/\Rybp⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3805329
ht3	\Rybp^tm1Nisa/\Rybp⁺	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:3805209

Allelic Composition	\Rybp^em1(IMPC)Bay/\Rybp⁺
Genetic Background	C57BL/6N-Rybp^em1(IMPC)Bay/Bay

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rybp^em1(IMPC)Bay mutation (1 available); any Rybp mutation (44 available)

Data Sources

IMPC Data for Rybp

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - BCM

abnormal locomotor behavior ( J:211773 )

IMPC - BCM

homeostasis/metabolism

decreased circulating alkaline phosphatase level ( J:211773 )

IMPC - BCM

Allelic Composition	\Rybp^tm1Nisa/\Rybp⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rybp^tm1Nisa mutation (0 available); any Rybp mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

optic nerve atrophy ( J:134428 )

• the optic nerve is frequently regressed in the retinas of E14.5 embryos

ventral rotation of lens ( J:134428 )

• lenses are ventrally rotated and misplaced within the eyeball in E14.5 embryos with coloboma

coloboma ( J:134428 )

• 32% of E14.5 embryos that are exencephalic also have retinal/optic nerve coloboma

• the colobomas occur both bilaterally and unilaterally and result from incomplete closure of the optic fissure

optic nerve coloboma ( J:134428 )

retina coloboma ( J:134428 )

retina hyperplasia ( J:134428 )

• the neuroretina is thickened in E14.5 embryos with coloboma

nervous system

optic nerve coloboma ( J:134428 )

optic nerve atrophy ( J:134428 )

• the optic nerve is frequently regressed in the retinas of E14.5 embryos

Allelic Composition	\Rybp^tm1Nisa/\Rybp⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rybp^tm1Nisa mutation (0 available); any Rybp mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:134591 )

• 15% of mice die at birth from exencephaly

nervous system

delayed neural tube closure ( J:134591 )

• some E10 embryos have neural tubes with openings at the forebrain/midbrain boundary

abnormal forebrain development ( J:134591 )

• forebrain overgrowth in the 15% of mice that have exencephaly

abnormal midbrain development ( J:134591 )

• disorganization and the absence of parts of the mid-brain are noted in the 15% of mice born with exencephaly

exencephaly ( J:134591 )

• 15% of mice are born with exencephaly

• excencephaly results from forebrain overgrowth and ventricular stenosis

embryo

delayed neural tube closure ( J:134591 )

• some E10 embryos have neural tubes with openings at the forebrain/midbrain boundary

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24