Phenotypes associated with this allele

• Allele Symbol: F2⁺
• Allele Name: wild type
• Allele ID: MGI:2436821
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	F2^tm2Jld/F2^+	B6.129P2-F2^tm2Jld	MGI:5140788
ht2	F2^tm1b(EUCOMM)Hmgu/F2^+	C57BL/6N-F2^tm1b(EUCOMM)Hmgu/H	MGI:5797523
ht3	F2^tm1Sjd/F2^+	involves: 129P2/OlaHsd	MGI:5140790
ht4	F2^tm2Jld/F2^+	involves: 129P2/OlaHsd * C57BL/6 * DBA/2J	MGI:5140789

Genotype
MGI:5140788

ht1

• Allelic Composition: F2^tm2Jld/F2⁺
• Genetic Background: B6.129P2-F2^tm2Jld

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating protein level ( J:174629 )

• LPS-treated mice exhibit a modest decrease in activated protein C serum and thrombin-antithrombin levels compared with similarly treated wild-type mice

decreased susceptibility to induced thrombosis ( J:174629 )

• following FeCl3 injury, mice exhibit extended time to complete vessel occlusion compared with similarly treated wild-type mice

increased bleeding time ( J:174629 )

immune system

decreased susceptibility to endotoxin shock ( J:174629 )

• LPS-treated mice exhibit a modest decrease in activated protein C serum and thrombin-antithrombin levels compared with similarly treated wild-type mice

• however, LPS-treated mice exhibit no survival advantage

Genotype
MGI:5797523

ht2

• Allelic Composition: F2^{tm1b(EUCOMM)Hmgu}/F2⁺
• Genetic Background: C57BL/6N-F2^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0720_4_G11

Data Sources

IMPC Data for F2

adipose tissue

increased total body fat amount ( J:211773 )

♂

IMPC - HAR

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - HAR

tremors ( J:211773 )

♂

IMPC - HAR

growth/size/body

decreased lean body mass ( J:211773 )

♂

IMPC - HAR

hematopoietic system

decreased mean corpuscular volume ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased circulating fructosamine level ( J:211773 )

♀

IMPC - HAR

increased circulating serum albumin level ( J:211773 )

♀

IMPC - HAR

skeleton

decreased bone mineral content ( J:211773 )

♂

IMPC - HAR

Genotype
MGI:5140790

ht3

• Allelic Composition: F2^tm1Sjd/F2⁺
• Genetic Background: involves: 129P2/OlaHsd

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:174629 )

N • mice exhibit normal bleed times and complete vessel occlusion following FeCl3 injury

Genotype
MGI:5140789

ht4

• Allelic Composition: F2^tm2Jld/F2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

immune system

decreased susceptibility to induced arthritis ( J:174629 )

• mice treated with collagen to induce arthritis exhibit reduced histologic features of inflammatory joint disease (inflammatory cell infiltrate, synovial hyperplasia, edema, pannus formation, and cartilage/bone degradation) compared with similarly treated wild-type mice

decreased synovial pannus formation ( J:174629 )

skeleton

decreased susceptibility to induced arthritis ( J:174629 )

• mice treated with collagen to induce arthritis exhibit reduced histologic features of inflammatory joint disease (inflammatory cell infiltrate, synovial hyperplasia, edema, pannus formation, and cartilage/bone degradation) compared with similarly treated wild-type mice

decreased synovial pannus formation ( J:174629 )