All Phenotypes Foxq1<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Foxq1⁺
wild type
MGI:2436678

Summary

17 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Foxq1^sa/Foxq1⁺ sau/sau⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:3607722
cx2	sau/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:3607793
cx3	Foxq1^sa/Foxq1⁺ Sox4^M91Ark/Del(13)36H	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:3819858
cx4	Foxq1^sa/Foxq1⁺ M1073b/Del(13)36H	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516034
cx5	Foxq1^sa/Foxq1⁺ M1073b/+	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516036
cx6	M1185b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516037
cx7	M1616b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516038
cx8	M1645b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516039
cx9	M241b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516040
cx10	M369b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516041
cx11	Foxq1^sa/Foxq1⁺ M369b/+	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516043
cx12	M412b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516044
cx13	M54b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516045
cx14	M624b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516046
cx15	M876b/Del(13)36H Foxq1^sa/Foxq1⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516047
cx16	Foxq1^sa/Foxq1⁺ M876b/+	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516049
cx17	Foxq1^sa/Foxq1⁺ Sox4^M91Ark/Sox4⁺	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR	MGI:5516058

Allelic Composition	Foxq1^sa/Foxq1⁺ sau/sau⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
sau mutation (2 available); any sau mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased thigmotaxis ( J:101156 )

• heterozygous mice exhibit heightened anxiety in the Open Field Activity test, entering the center of the field 29% less frequently than littermate controls

Allelic Composition	sau/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
sau mutation (2 available); any sau mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:101156 )

• hemizygous progeny are born at less than one-third the expected Mendelian frequency, most dying by 16.5 days post coitum (16.5 dpc)

nervous system

holoprosencephaly ( J:101156 )

• hemizygous embyros examined at 9.5 dpc often exhibit midline forebrain defects and other aspects of holoprocencephaly

• some hemizygotes that survive to birth exhibit holoprosencephalic phenotypes of varying severity

vision/eye

abnormal eye development ( J:101156 )

• some hemizygous embryos and liveborn pups exhibit structural eye defects

cyclopia ( J:101156 )

Allelic Composition	Foxq1^sa/Foxq1⁺ Sox4^M91Ark/Del(13)36H
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
Sox4^M91Ark mutation (2 available); any Sox4 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:101156 )

• almost all mice die before birth, with a significant deviation from expected Mendelian frequencies first noted at E14.5

cardiovascular system

abnormal aortic arch morphology ( J:101156 )

• smaller than the pulmonary artery

abnormal cardiovascular development ( J:101156 )

• circulatory failure

abnormal heart morphology ( J:101156 )

abnormal heart development ( J:101156 )

• common atrioventricular junction

double outlet right ventricle ( J:101156 )

• the aorta and pulmonary artery both originate from the right ventricle

abnormal mitral valve morphology ( J:101156 )

• the mitral valve of E14.5 embryos is dysplastic

ostium primum atrial septal defect ( J:101156 )

• a primum atrial septal defect is seen at the ventral margin of the primary atrial septum in E14.5 embryos

ventricular septal defect ( J:101156 )

• a large ventricular septum defect connects the left and right ventricles

renal/urinary system

abnormal kidney development ( J:101156 )

• kidneys of E14.5 embryos are hypoplastic and occasionally positioned abnormally

renal hypoplasia ( J:101156 )

nervous system

holoprosencephaly ( J:101156 )

Allelic Composition	Foxq1^sa/Foxq1⁺ M1073b/Del(13)36H
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
M1073b mutation (2 available); any M1073b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

craniofacial

abnormal craniofacial morphology ( J:101156 )

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

abnormal palate morphology ( J:101156 )

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

hearing/vestibular/ear

abnormal ear morphology ( J:101156 )

vision/eye

abnormal eye morphology ( J:101156 )

digestive/alimentary system

abnormal palate morphology ( J:101156 )

skeleton

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

growth/size/body

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

abnormal palate morphology ( J:101156 )

microcephaly ( J:101156 )

Allelic Composition	Foxq1^sa/Foxq1⁺ M1073b/+
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
M1073b mutation (2 available); any M1073b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased anxiety-related response ( J:101156 )

• increased cumulative center entries in an open field

Allelic Composition	M1185b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
M1185b mutation (2 available); any M1185b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:101156 )

• lethality occurs in the second half of gestation

cardiovascular system

abnormal heart morphology ( J:101156 )

Allelic Composition	M1616b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
M1616b mutation (2 available); any M1616b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:101156 )

• lethality occurs in the second half of gestation

embryo

failure of chorioallantoic fusion ( J:101156 )

Allelic Composition	M1645b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
M1645b mutation (2 available); any M1645b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:101156 )

• lethality occurs in the second half of gestation

Allelic Composition	M241b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
M241b mutation (2 available); any M241b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:101156 )

• lethality occurs in the second half of gestation

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

vision/eye

anophthalmia ( J:101156 )

• without micrognathia

Allelic Composition	M369b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
M369b mutation (2 available); any M369b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

nervous system

exencephaly ( J:101156 )

Allelic Composition	Foxq1^sa/Foxq1⁺ M369b/+
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
M369b mutation (2 available); any M369b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:101156 )

• increased activity and center entries in an open field

Allelic Composition	M412b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
M412b mutation (2 available); any M412b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

craniofacial

abnormal craniofacial morphology ( J:101156 )

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

abnormal palate morphology ( J:101156 )

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

abnormal lateral ventricle morphology ( J:101156 )

• hypoplastic with no development of the interhemispheric fissure

abnormal hindbrain morphology ( J:101156 )

hearing/vestibular/ear

abnormal ear morphology ( J:101156 )

vision/eye

abnormal eye morphology ( J:101156 )

digestive/alimentary system

abnormal palate morphology ( J:101156 )

skeleton

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

growth/size/body

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

abnormal palate morphology ( J:101156 )

microcephaly ( J:101156 )

Allelic Composition	M54b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
M54b mutation (2 available); any M54b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

craniofacial

abnormal craniofacial morphology ( J:101156 )

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

abnormal palate morphology ( J:101156 )

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

abnormal lateral ventricle morphology ( J:101156 )

• hypoplastic with no development of the interhemispheric fissure

hearing/vestibular/ear

abnormal ear morphology ( J:101156 )

• absence of ear pinnae at E15.5

vision/eye

anophthalmia ( J:101156 )

digestive/alimentary system

abnormal palate morphology ( J:101156 )

skeleton

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

growth/size/body

abnormal tooth morphology ( J:101156 )

absent mandible ( J:101156 )

• microagnathia/agnathia

micrognathia ( J:101156 )

• microagnathia/agnathia

abnormal palate morphology ( J:101156 )

microcephaly ( J:101156 )

Allelic Composition	M624b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
M624b mutation (2 available); any M624b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

nervous system

holoprosencephaly ( J:101156 )

abnormal forebrain morphology ( J:101156 )

vision/eye

abnormal eye morphology ( J:101156 )

• a single, ventrally displaced eye

Allelic Composition	M876b/Del(13)36H Foxq1^sa/Foxq1⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13)36H mutation (0 available); any Del(13)36H mutation (0 available)
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
M876b mutation (2 available); any M876b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:101156 )

• lethality occurs in the second half of gestation

Allelic Composition	Foxq1^sa/Foxq1⁺ M876b/+
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
M876b mutation (2 available); any M876b mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased anxiety-related response ( J:101156 )

• decreased cumulative center entries in an open field

nervous system

decreased prepulse inhibition ( J:101156 )

Allelic Composition	Foxq1^sa/Foxq1⁺ Sox4^M91Ark/Sox4⁺
Genetic Background	involves: 101 * BALB/cOlaHsd * C3H * C57BL/6J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxq1^sa mutation (16 available); any Foxq1 mutation (30 available)
Sox4^M91Ark mutation (2 available); any Sox4 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased anxiety-related response ( J:101156 )

• mice have a 31% decrease compared to controls in how many times the central portion of an open field test is entered

• mice also have additional reductions in total distance traveled (22% decrease) and movement time (14% decrease) in the open field tests

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/06/2026 MGI 6.24