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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dcx+
wild type
MGI:2436640
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Dcxtm1Caw/Dcx+ involves: 129S6/SvEvTac * 129X1/SvJ MGI:3618280
ht2
 		Dcxtm1Caw/Dcx+ involves: 129S6/SvEvTac * 129X1/SvJ * Black Swiss MGI:3618275
cx3
 		Dclk1tm1.1Jgg/Dclk1tm1.1Jgg
Dcxtm1Caw/Dcx+ 		involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 MGI:3618310
cx4
 		Dclk1tm1Caw/Dclk1tm1Caw
Dcxtm1Caw/Dcx+ 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J MGI:3628584
cx5
 		Dclk1tm1Caw/Dclk1+
Dcxtm1Caw/Dcx+ 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J MGI:3628593


Genotype
MGI:3618280
ht1
Allelic
Composition		 Dcxtm1Caw/Dcx+
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcxtm1Caw mutation (0 available); any Dcx mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal avoidance learning behavior ( J:78746 )
• female mice show impaired ability to associate stimulus (tone) with unconditioned stimulus (shock) in the fear test
abnormal spatial learning ( J:78746 )
• animals demonstrate mild deficits in latency to find hidden platform in Morris water maze test
decreased grip strength ( J:78746 )
• female heterozygous mice show deficits in cage-top hang tests




Genotype
MGI:3618275
ht2
Allelic
Composition		 Dcxtm1Caw/Dcx+
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcxtm1Caw mutation (0 available); any Dcx mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampus morphology ( J:78746 )
• hippocampal formation is malformed
abnormal hippocampus pyramidal cell layer ( J:78746 )
• pyramidal layer of CA3 is split in some regions
• pyramidal neurons are more loosely arrayed in some animals
• milder dispruptions of the pyramidal layerare seen in CA2 and CA1 regions

behavior/neurological
abnormal avoidance learning behavior ( J:78746 )
• female mice showed impaired ability to associate stimulus (tone) with unconditioned stimulus (shock) in a fear test
decreased grip strength ( J:78746 )
• female mice show deficits in cage-top hang tests




Genotype
MGI:3618310
cx3
Allelic
Composition		 Dclk1tm1.1Jgg/Dclk1tm1.1Jgg
Dcxtm1Caw/Dcx+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1.1Jgg mutation (0 available); any Dclk1 mutation (55 available)
Dcxtm1Caw mutation (0 available); any Dcx mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
absent corpus callosum ( J:105300 )
• corpus callosum is absent
abnormal anterior commissure morphology ( J:105300 )
• anterior commissure is hypoplastic
abnormal stratification in cerebral cortex ( J:105300 )
• cytoarchitectonics are disrupted; there is dispersion of the cell-rich layer 2/3




Genotype
MGI:3628584
cx4
Allelic
Composition		 Dclk1tm1Caw/Dclk1tm1Caw
Dcxtm1Caw/Dcx+
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1Caw mutation (0 available); any Dclk1 mutation (55 available)
Dcxtm1Caw mutation (0 available); any Dcx mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced female fertility ( J:105301 )
• fertility appears to be reduced




Genotype
MGI:3628593
cx5
Allelic
Composition		 Dclk1tm1Caw/Dclk1+
Dcxtm1Caw/Dcx+
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1tm1Caw mutation (0 available); any Dclk1 mutation (55 available)
Dcxtm1Caw mutation (0 available); any Dcx mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced female fertility ( J:105301 )
• fertility appears to be reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory