All Phenotypes Yap1<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Yap1^tm1.1Hmc/Yap1⁺	involves: 129S6/SvEvTac * BALB/c * C57BL/6 * C57BL/6NCrl	MGI:6716878
cn2	Wwtr1^tm1.2Hmc/Wwtr1^tm1.2Hmc Yap1^tm1.2Hmc/Yap1⁺ Tg(Myh11-cre,-EGFP)2Mik/0	involves: 129 * C57BL/6 * DBA/2	MGI:7861681
cn3	Nf2^tm2Gth/Nf2^tm2Gth Yap1^tm1.1Dupa/Yap1⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:4819843
cn4	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} Yap1^tm1.1Fcam/Yap1⁺ Tg(Tek-cre)1Ywa/0	involves: 129S4/SvJae * C57BL/6N * CBA * SJL	MGI:6360911
cn5	Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1⁺ Tg(Myh6-cre)2182Mds/0	involves: 129S/SvEv * FVB/N	MGI:5544296
cx6	Tead1^tm1Hssk/Tead1⁺ Tead2^tm1Hssk/Tead2^tm1Hssk Yap1^tm1Smil/Yap1⁺	either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)	MGI:3797240
cx7	Tead1^tm1Hssk/Tead1^tm1Hssk Tead2^tm1Hssk/Tead2⁺ Yap1^tm1Smil/Yap1⁺	either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)	MGI:3797243

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:304126 )

• cataract is occasionally seen but only in about 8% of retinas

abnormal retina morphology ( J:304126 )

• retinal dysplasia, with highly variable severity

• from P21 onwards, some retinas show one or two dysplastic regions in either the central or dorsal retina; incidence of this phenotype is higher in older mice

• retinal dysplasia is never seen in the retinal pigment epithelium and no difference in the thickness of either the outer or the inner nuclear layers

• however, no defects in optic fissure closure are seen

decreased retina cone cell number ( J:304126 )

• the number of cones is decreased in ventral retinas, affecting both S-opsin and M-opsin labelled cones

• S-opsin labelled cones are also severely decreased in the mid-dorsal and the central retina

retina cone cell degeneration ( J:304126 )

• adults show progressive cone photoreceptor degeneration

abnormal retina progenitor cell morphology ( J:304126 )

• mice show a persistence of a population of proliferative cells in P6 retinas but not at P11, indicating that retinal progenitor cells show delayed cell-cycle exit in postnatal mice, eventually exiting the cell cycle between P6 and P11

retina gliosis ( J:304126 )

• GFAP expression is increased in 12-month-old retina indicating reactive gliosis

abnormal electroretinogram waveform feature ( J:304126 )

• mice show a reduction of the cone-mediated ERG response

• however, scotopic a- and b-waves are similar to controls at all stages, indicating normal rod photoreceptor function

decreased b-wave amplitude ( J:304126 )

• photopic b-wave amplitude is depressed in 12-month-old mice at high intensity stimuli

nervous system

abnormal glial cell physiology ( J:304126 )

• marker analysis indicates altered Muller cell homeostatic function in aged mice

decreased retina cone cell number ( J:304126 )

• the number of cones is decreased in ventral retinas, affecting both S-opsin and M-opsin labelled cones

• S-opsin labelled cones are also severely decreased in the mid-dorsal and the central retina

retina cone cell degeneration ( J:304126 )

• adults show progressive cone photoreceptor degeneration

abnormal ribbon synapse morphology ( J:304126 )

• 12-month-old retina shows a decrease in the number of Ribeye+ puncta, representing presynaptic ribbons, in photoreceptor terminals

• some ribbons do not exhibit the typical horseshoe shape suggesting compromised synapse integrity

• however, ribbons with proper shape are still present close to dendritic process of the rod-bipolar cell postsynaptic terminals, indicating a correct synaptic connection between rod photoreceptor and rod-bipolar cells

cellular

abnormal glial cell physiology ( J:304126 )

• marker analysis indicates altered Muller cell homeostatic function in aged mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cone dystrophy		DOID:0050795		J:304126

Allelic Composition	Wwtr1^tm1.2Hmc/Wwtr1^tm1.2Hmc Yap1^tm1.2Hmc/Yap1⁺ Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background	involves: 129 * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
Wwtr1^tm1.2Hmc mutation (2 available); any Wwtr1 mutation (23 available)
Yap1^tm1.2Hmc mutation (1 available); any Yap1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitochondrial physiology ( J:344215 )

• aortic vascular smooth muscle (VSM) mitochondria show significantly lower maximal oxygen consumption and spare respiratory capacity, similar to what is observed in mice double homozygous for Wnt16^{tm2a(EUCOMM)Wtsi} and Ldlr^tm1Her

Allelic Composition	Nf2^tm2Gth/Nf2^tm2Gth Yap1^tm1.1Dupa/Yap1⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2^tm2Gth mutation (3 available); any Nf2 mutation (67 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
Yap1^tm1.1Dupa mutation (2 available); any Yap1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:162628 )

N	• mice do not exhibit bile duct proliferation

enlarged liver ( J:162628 )

• slightly

neoplasm

neoplasm ( J:162628 )

N	• mice do not develop bile duct hamartomas or hepatocellular carcinoma

growth/size/body

enlarged liver ( J:162628 )

• slightly

Allelic Composition	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} Yap1^tm1.1Fcam/Yap1⁺ Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S4/SvJae * C57BL/6N * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tek-cre)1Ywa mutation (7 available)
Vgll4^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Vgll4 mutation (24 available)
Vgll4^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Vgll4 mutation (24 available)
Yap1^tm1.1Fcam mutation (0 available); any Yap1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:273437 )

N	• hearts are normal morphology and function with normal valve thickness and cardiomyocyte proliferation and apoptosis rates

Allelic Composition	Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1⁺ Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129S/SvEv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation (3 available)
Wwtr1^tm1.1Eno mutation (0 available); any Wwtr1 mutation (23 available)
Yap1^tm1.1Eno mutation (0 available); any Yap1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cardiomyopathy in Wwtr1^tm1.2Eno/Wwtr1^tm1.2Eno Yap1^tm1.1Eno/Yap1⁺ Tg(Myh6-cre)2182Mds/0 mice

mortality/aging

premature death ( J:200670 )

• complete lethality by 33 weeks of age from heart failure

cardiovascular system

dilated cardiomyopathy ( J:200670 )

• grossly dilated at 30 weeks of age but seen as early as 8 days of age

homeostasis/metabolism

abnormal atrial thrombosis ( J:200670 )

• at 30 weeks of age

muscle

dilated cardiomyopathy ( J:200670 )

• grossly dilated at 30 weeks of age but seen as early as 8 days of age

Allelic Composition	Tead1^tm1Hssk/Tead1⁺ Tead2^tm1Hssk/Tead2^tm1Hssk Yap1^tm1Smil/Yap1⁺
Genetic Background	either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tead1^tm1Hssk mutation (1 available); any Tead1 mutation (276 available)
Tead2^tm1Hssk mutation (1 available); any Tead2 mutation (34 available)
Yap1^tm1Smil mutation (0 available); any Yap1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal developmental patterning ( J:131426 )

• mutants exhibit smaller posterior tissues

abnormal embryo turning ( J:131426 )

• defective embryonic turning

Allelic Composition	Tead1^tm1Hssk/Tead1^tm1Hssk Tead2^tm1Hssk/Tead2⁺ Yap1^tm1Smil/Yap1⁺
Genetic Background	either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:131426 )

• mutants show essentially the same morphological defects as double Tead1 and Tead2 homozygotes

abnormal embryonic tissue morphology ( J:131426 )

• embryos develop a posterior-ventral protrusion

abnormal allantois morphology ( J:131426 )

• embryos develop a bulbous allantois

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