All Phenotypes Ncoa6<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ncoa6^tm1Hhs/Ncoa6⁺	129S6/SvEvTac-Ncoa6^tm1Hhs	MGI:3046465
ht2	Ncoa6^em1(IMPC)J/Ncoa6⁺	C57BL/6NJ-Ncoa6^em1(IMPC)J/J	MGI:5884014
ht3	Ncoa6^tm1Hhs/Ncoa6⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:3046500
cn4	Ncoa6^tm1Jkr/Ncoa6⁺ Tg(Myh6-cre)2182Mds/0	involves: 129P2/OlaHsd * FVB/N	MGI:6276352
cx5	Ncoa6^tm3.1Jxu/Ncoa6⁺ Tg(Cryaa-NCOA6*)AD5Cve/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:4837889

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:91083 )

• Background Sensitivity: increased neonatal lethality is seen on a 129S6 background but not on a mixed 129S6 and C57BL/6 background

prenatal lethality, incomplete penetrance ( J:91083 )

• on a 129S6 background fewer than expected heterozygous embryos are born; however, embryonic lethality is not seen on a mixed 129S6 and C57BL/6 background

endocrine/exocrine glands

increased sebaceous gland number ( J:91083 )

• those heterozygotes that develop spontaneous wounds display an increase in the number of sebaceous glands

growth/size/body

decreased birth body size ( J:91083 )

• Background Sensitivity: neonates are small compared to wild-type, this occurs more frequently on a 129S6 background than on a mixed 129S6 and C57BL/6 background

decreased birth weight ( J:91083 )

• about 3% of the neonates on a 129S6 background weigh less than 70% of wild-type littermates and these often die before weaning

• the weight difference between heterozygous pups and wild-type littermates decreases between 1 - 2 months after birth

reproductive system

female infertility ( J:91083 )

• about 20% of females on a 129S6 background are infertile

reduced female fertility ( J:91083 )

• about 80% of females on a 129S6 background produce small litters when crossed to either wild-type or heterozygous males

• Background Sensitivity: on a 129S6 background female fertility progressively decreases with repeated crossings

decreased litter size ( J:91083 )

• Background Sensitivity: heterozygous males and females produce small litters when on a 129S6 background but not when on a mixed 129S6/SvEv and C57BL/6 background

reduced male fertility ( J:91083 )

• Background Sensitivity: on a 129S6 background males mated to wild-type females sire small litters; however, on a mixed 129S6 and C57BL/6 background fertility is not reduced

homeostasis/metabolism

delayed wound healing ( J:91083 )

• about 20% of heterozygotes develop spontaneous wounds around the head and neck and of these 25% show delayed wound healing

impaired wound healing ( J:91083 )

• about 20% of heterozygotes develop spontaneous wounds around the head and neck and for 75% of these 75% the wound does not heal

• no leading edge of keratinocyte migration is seen and in skin explant culture keratinocyte migratory capacity is significantly reduced

integument

increased sebaceous gland number ( J:91083 )

• those heterozygotes that develop spontaneous wounds display an increase in the number of sebaceous glands

decreased hair follicle number ( J:91083 )

• those heterozygotes that develop spontaneous wounds display a decrease in or total loss of hair follicles

thick epidermis ( J:91083 )

• those heterozygotes that develop spontaneous wounds display thickening of the epidermis around the wound

Allelic Composition	Ncoa6^em1(IMPC)J/Ncoa6⁺
Genetic Background	C57BL/6NJ-Ncoa6^em1(IMPC)J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa6^em1(IMPC)J mutation (1 available); any Ncoa6 mutation (101 available)

Data Sources

IMPC Data for Ncoa6

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - JAX

vision/eye

abnormal retina morphology ( J:211773 )

IMPC - JAX

Allelic Composition	Ncoa6^tm1Hhs/Ncoa6⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa6^tm1Hhs mutation (0 available); any Ncoa6 mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased sebaceous gland number ( J:91083 )

• those heterozygotes that develop spontaneous wounds display an increase in the number of sebaceous glands around the wound site

growth/size/body

decreased birth body size ( J:91083 )

• Background Sensitivity: neonates are small compared to wild-type, this occurs more frequently on a 129S6 background than on a mixed 129S6/SvEv and C57BL/6 background

reproductive system

reproductive system phenotype ( J:91083 )

N	• heterozygotes display normal fertility on a mixed 129S6 and C57BL/6 background

homeostasis/metabolism

delayed wound healing ( J:91083 )

• about 20% of heterozygotes develop spontaneous wounds around the head and neck and of these 25% show delayed wound healing

impaired wound healing ( J:91083 )

• about 20% of heterozygotes develop spontaneous wounds around the head and neck and for 75% of these 75% the wound does not heal

• no leading edge of keratinocyte migration is seen and in skin explant culture keratinocyte migratory capacity is significantly reduced

integument

increased sebaceous gland number ( J:91083 )

• those heterozygotes that develop spontaneous wounds display an increase in the number of sebaceous glands around the wound site

decreased hair follicle number ( J:91083 )

• those heterozygotes that develop spontaneous wounds display a decrease in or total loss of hair follicles around the wound site

thick epidermis ( J:91083 )

• those heterozygotes that develop spontaneous wounds display thickening of the epidermis around the wound

Allelic Composition	Ncoa6^tm1Jkr/Ncoa6⁺ Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa6^tm1Jkr mutation (0 available); any Ncoa6 mutation (101 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dilated cardiomyopathy ( J:269856 )

• mice exhibit characteristics of dilated cardiomyopathy with late onset

decreased cardiac muscle contractility ( J:269856 )

• decrease in percent fractional shortening

abnormal heart echocardiography feature ( J:269856 )

• echocardiography indicates decreased fractional shortening and enlarged left ventricular end-systolic dimensions and end-diastolic dimensions

muscle

dilated cardiomyopathy ( J:269856 )

• mice exhibit characteristics of dilated cardiomyopathy with late onset

decreased cardiac muscle contractility ( J:269856 )

• decrease in percent fractional shortening

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:269856

Allelic Composition	Ncoa6^tm3.1Jxu/Ncoa6⁺ Tg(Cryaa-NCOA6*)AD5Cve/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa6^tm3.1Jxu mutation (0 available); any Ncoa6 mutation (101 available)
Tg(Cryaa-NCOA6*)AD5Cve mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

small lens ( J:165054 )

• compared with Tg(Cryaa-NCOA6*)AD5Cve mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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