About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptpn6+
wild type
MGI:2436118
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ptpn6m3Btlr/Ptpn6+ C57BL/6J-Ptpn6m3Btlr MGI:5789724
cx2
 		Ptpn6me-v/Ptpn6+
Tg(IghelMD4)4Ccg/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3852086
cx3
 		Lyntm1Ard/Lyn+
Ptpn6me-v/Ptpn6+
Tg(IghelMD4)4Ccg/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3852087
cx4
 		Cd22tm1Eac/Cd22+
Lyntm1Ard/Lyn+
Ptpn6me-v/Ptpn6+
Tg(IghelMD4)4Ccg/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3852089
cx5
 		Cd22tm1Eac/Cd22+
Ptpn6me-v/Ptpn6+
Tg(IghelMD4)4Ccg/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3852090


Genotype
MGI:5789724
ht1
Allelic
Composition		 Ptpn6m3Btlr/Ptpn6+
Genetic
Background		 C57BL/6J-Ptpn6m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn6m3Btlr mutation (0 available); any Ptpn6 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased dendritic cell number ( J:234259 )
• a slight increase in the frequency of CD11c+ dendritic cells in the peripheral blood
increased B-1 B cell number ( J:234259 )
• a slight increase in the frequency of B1 cells in the peripheral blood
increased B-1a cell number ( J:234259 )
• a slight increase in the frequency of B1a cells in the peripheral blood
decreased B cell number ( J:234259 )
• a slight decrease in the frequency of B cells in the peripheral blood
decreased immature B cell number ( J:234259 )
• a slight decrease in the frequency of IgM+ B cells in the peripheral blood
decreased mature B cell number ( J:234259 )
• a slight decrease in the percentage of IgD+ B cells in the peripheral blood
decreased B-2 B cell number ( J:234259 )
• a slight decrease in the frequency of B2 cells in the peripheral blood
increased macrophage cell number ( J:234259 )
• a slight increase in the frequency of macrophages in the peripheral blood
abnormal CD8-positive, alpha beta T cell morphology ( J:234259 )
• a slight increase in the CD44 mean fluorescence intensity on CD8+ T cells in the peripheral blood

hematopoietic system
increased dendritic cell number ( J:234259 )
• a slight increase in the frequency of CD11c+ dendritic cells in the peripheral blood
increased B-1 B cell number ( J:234259 )
• a slight increase in the frequency of B1 cells in the peripheral blood
increased B-1a cell number ( J:234259 )
• a slight increase in the frequency of B1a cells in the peripheral blood
decreased B cell number ( J:234259 )
• a slight decrease in the frequency of B cells in the peripheral blood
decreased immature B cell number ( J:234259 )
• a slight decrease in the frequency of IgM+ B cells in the peripheral blood
decreased mature B cell number ( J:234259 )
• a slight decrease in the percentage of IgD+ B cells in the peripheral blood
decreased B-2 B cell number ( J:234259 )
• a slight decrease in the frequency of B2 cells in the peripheral blood
increased macrophage cell number ( J:234259 )
• a slight increase in the frequency of macrophages in the peripheral blood
abnormal CD8-positive, alpha beta T cell morphology ( J:234259 )
• a slight increase in the CD44 mean fluorescence intensity on CD8+ T cells in the peripheral blood




Genotype
MGI:3852086
cx2
Allelic
Composition		 Ptpn6me-v/Ptpn6+
Tg(IghelMD4)4Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn6me-v mutation (4 available); any Ptpn6 mutation (47 available)
Tg(IghelMD4)4Ccg mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mature B cell morphology ( J:110531 )
• mature B cells have about 2-fold lower surface IgM levels

hematopoietic system
abnormal mature B cell morphology ( J:110531 )
• mature B cells have about 2-fold lower surface IgM levels




Genotype
MGI:3852087
cx3
Allelic
Composition		 Lyntm1Ard/Lyn+
Ptpn6me-v/Ptpn6+
Tg(IghelMD4)4Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyntm1Ard mutation (7 available); any Lyn mutation (67 available)
Ptpn6me-v mutation (4 available); any Ptpn6 mutation (47 available)
Tg(IghelMD4)4Ccg mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal mature B cell morphology ( J:110531 )
• mature B cells have about 4-fold lower surface IgM levels

immune system
abnormal mature B cell morphology ( J:110531 )
• mature B cells have about 4-fold lower surface IgM levels




Genotype
MGI:3852089
cx4
Allelic
Composition		 Cd22tm1Eac/Cd22+
Lyntm1Ard/Lyn+
Ptpn6me-v/Ptpn6+
Tg(IghelMD4)4Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Eac mutation (1 available); any Cd22 mutation (59 available)
Lyntm1Ard mutation (7 available); any Lyn mutation (67 available)
Ptpn6me-v mutation (4 available); any Ptpn6 mutation (47 available)
Tg(IghelMD4)4Ccg mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell negative selection ( J:110531 )
• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is almost completely blocked at the immature B cell stage
abnormal mature B cell morphology ( J:110531 )
• surface expression of IgM is only 15% of controls
increased IgM level ( J:110531 )
• half the mice have a 15-fold increase in Hel-specific serum IgM

hematopoietic system
abnormal B cell negative selection ( J:110531 )
• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is almost completely blocked at the immature B cell stage
abnormal mature B cell morphology ( J:110531 )
• surface expression of IgM is only 15% of controls
increased IgM level ( J:110531 )
• half the mice have a 15-fold increase in Hel-specific serum IgM




Genotype
MGI:3852090
cx5
Allelic
Composition		 Cd22tm1Eac/Cd22+
Ptpn6me-v/Ptpn6+
Tg(IghelMD4)4Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Eac mutation (1 available); any Cd22 mutation (59 available)
Ptpn6me-v mutation (4 available); any Ptpn6 mutation (47 available)
Tg(IghelMD4)4Ccg mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell negative selection ( J:110531 )
• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is partially blocked at the immature B cell stage
abnormal mature B cell morphology ( J:110531 )
• surface expression of IgM is less than half of controls

hematopoietic system
abnormal B cell negative selection ( J:110531 )
• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is partially blocked at the immature B cell stage
abnormal mature B cell morphology ( J:110531 )
• surface expression of IgM is less than half of controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory