All Phenotypes Grb2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grb2⁺
wild type
MGI:2436070

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Grb2^tm1Paw/Grb2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:2679600
ht2	Grb2^tm1Paw/Grb2⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/c	MGI:3714659
cn3	Grb2^tm1Paw/Grb2⁺ Pten^tm2Mak/Pten^tm2Mak Tg(Lck-cre)548Jxm/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3717275
cx4	Grb2^tm1Paw/Grb2⁺ Pten^tm1Mak/Pten⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3717274
cx5	Grb2^tm1Paw/Grb2⁺ Tg(MMTV-PyVT)634Mul/?	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:2679599

Allelic Composition	Grb2^tm1Paw/Grb2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:51424 )

Allelic Composition	Grb2^tm1Paw/Grb2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to Retroviridae infection ( J:122429 )

• mice exhibit reduced susceptibility to Friend erythroleukemia virus (FV)

• spleen size following FV infection is not as inflamed as in wild-type mice

Allelic Composition	Grb2^tm1Paw/Grb2⁺ Pten^tm2Mak/Pten^tm2Mak Tg(Lck-cre)548Jxm/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (45 available)
Pten^tm2Mak mutation (4 available); any Pten mutation (86 available)
Tg(Lck-cre)548Jxm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:93530 )

• thymic lymphomas develop with a mean age of onset of 60 days, similar to that seen in T cell-specific Pten homozygotes

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:93530 )

• thymic lymphomas develop with a mean age of onset of 60 days, similar to that seen in T cell-specific Pten homozygotes

immune system

increased T cell derived lymphoma incidence ( J:93530 )

• thymic lymphomas develop with a mean age of onset of 60 days, similar to that seen in T cell-specific Pten homozygotes

hematopoietic system

increased T cell derived lymphoma incidence ( J:93530 )

• thymic lymphomas develop with a mean age of onset of 60 days, similar to that seen in T cell-specific Pten homozygotes

Allelic Composition	Grb2^tm1Paw/Grb2⁺ Pten^tm1Mak/Pten⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (45 available)
Pten^tm1Mak mutation (1 available); any Pten mutation (86 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:93530 )

mortality/aging

mortality/aging ( J:93530 )

N	• the embryonic lethality seen in Pten^tm1Mak heterozygotes is completely rescued

neoplasm

increased tumor incidence ( J:93530 )

• develop the same tumor types at the same frequency as Pten^tm1Mak heterozygotes, including neoplastic lesions in the breast, endometrium, prostate, adrenal gland, and lymphoid organs; tumor stage, grade, and metastatic potential are similar to that in Pten^tm1Mak heterozygotes

increased adrenal gland tumor incidence ( J:93530 )

increased lymphoma incidence ( J:93530 )

increased endometrial carcinoma incidence ( J:93530 )

reproductive system

increased endometrial carcinoma incidence ( J:93530 )

Allelic Composition	Grb2^tm1Paw/Grb2⁺ Tg(MMTV-PyVT)634Mul/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (45 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:51424 )

• delayed onset of mammary tumorigenesis compared to wild-type Grb2 mice carrying transgene

integument

increased mammary adenocarcinoma incidence ( J:51424 )

• delayed onset of mammary tumorigenesis compared to wild-type Grb2 mice carrying transgene

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:51424 )

• delayed onset of mammary tumorigenesis compared to wild-type Grb2 mice carrying transgene

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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