All Phenotypes Rasgrf1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rasgrf1⁺
wild type
MGI:2435805

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rasgrf1^tm1Toc/Rasgrf1⁺	involves: 129	MGI:3848827
ht2	Rasgrf1^tm2Pds/Rasgrf1⁺	involves: 129S4/SvJae	MGI:3620518
ht3	Rasgrf1^tm1Pds/Rasgrf1⁺	involves: 129S4/SvJae * C57BL/6	MGI:3838176
ht4	Rasgrf1^tm4.1Pds/Rasgrf1⁺	involves: 129S4/SvJaeSor * C57BL/6	MGI:3620519
ht5	Rasgrf1^enu1H/Rasgrf1⁺	involves: BALB/c * C3H/HeN	MGI:2670341
ht6	Rasgrf1^enu2H/Rasgrf1⁺	involves: BALB/c * C3H/HeN	MGI:2670343
ht7	Rasgrf1^enu1H/Rasgrf1⁺	involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd	MGI:2670344
ht8	Rasgrf1^enu2H/Rasgrf1⁺	involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd	MGI:2670342
ht9	Rasgrf1^tm3.1Pds/Rasgrf1⁺	involves: FVB/N	MGI:3719685
cn10	Meox2^tm1(cre)Sor/Meox2⁺ Rasgrf1^tm4.1Pds/Rasgrf1⁺	involves: 129S4/SvJaeSor * C57BL/6	MGI:3698139
cn11	Rasgrf1^tm4.1Pds/Rasgrf1⁺ Tg(Zp3-cre)3Mrt/0	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:3698138
cn12	Rasgrf1^tm4.1Pds/Rasgrf1⁺ Tg(Nes-cre)1Kln/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:3698137

Allelic Composition	Rasgrf1^tm1Toc/Rasgrf1⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1^tm1Toc mutation (0 available); any Rasgrf1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:47681 )

• when the mutant allele is paternally inherited

• weight at 3-4 weeks of age is reduced 25% in females and 30% in males

• adults are persistently 15-25% smaller

postnatal growth retardation ( J:47681 )

• postnatal growth is slower when the mutant allele is paternally inherited

endocrine/exocrine glands

abnormal pituitary secretion ( J:47681 )

• pituitary growth hormone levels are reduced 42-53% when the mutant allele is paternally inherited

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:47681 )

• reduced 32-40% at 4 weeks of age when the mutant allele is paternally inherited

decreased growth hormone level ( J:47681 )

• contained 42-53% less growth hormone than the wild-type controls when the mutant allele is paternally inherited

cellular

maternal imprinting ( J:47681 )

nervous system

abnormal pituitary secretion ( J:47681 )

• pituitary growth hormone levels are reduced 42-53% when the mutant allele is paternally inherited

Allelic Composition	Rasgrf1^tm2Pds/Rasgrf1⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1^tm2Pds mutation (1 available); any Rasgrf1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal DNA methylation ( J:103751 )

abnormal imprinting ( J:103751 )

• loss of paternal allele methylation in mice with paternal transmission

• maternal transmission of the mutated allele had no effect on methylation

Allelic Composition	Rasgrf1^tm1Pds/Rasgrf1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1^tm1Pds mutation (0 available); any Rasgrf1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal imprinting ( J:75397 )

• methylation of the paternal differential methylation domain is blocked which prevents gene expression

Allelic Composition	Rasgrf1^tm4.1Pds/Rasgrf1⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1^tm4.1Pds mutation (0 available); any Rasgrf1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:117666 )

• DNA methylation of and Rasgrf1 expression from floxed allele are unaffected

Allelic Composition	Rasgrf1^enu1H/Rasgrf1⁺
Genetic Background	involves: BALB/c * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1^enu1H mutation (2 available); any Rasgrf1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:84625 )

• 15% decrease in total body weight when the mutant allele is transmitted by the male

postnatal growth retardation ( J:84625 )

• observed when mutant allele is transmitted by the male

cellular

maternal imprinting ( J:84625 )

• growth retardation and decreased body size when the allele is transmitted by the male

Allelic Composition	Rasgrf1^enu2H/Rasgrf1⁺
Genetic Background	involves: BALB/c * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1^enu2H mutation (2 available); any Rasgrf1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:84625 )

• 15% decrease in total body weight when the mutant allele is transmitted by the male

postnatal growth retardation ( J:84625 )

• observed when mutant allele is transmitted by the male

cellular

maternal imprinting ( J:84625 )

• growth retardation and decreased body size when the allele is transmitted by the male

Allelic Composition	Rasgrf1^enu1H/Rasgrf1⁺
Genetic Background	involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1^enu1H mutation (2 available); any Rasgrf1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:84625 )

• 15% decrease in total body weight when the mutant allele is transmitted by the male

postnatal growth retardation ( J:84625 )

• observed when mutant allele is transmitted by the male

cellular

maternal imprinting ( J:84625 )

• growth retardation and decreased body size when the allele is transmitted by the male

Allelic Composition	Rasgrf1^enu2H/Rasgrf1⁺
Genetic Background	involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1^enu2H mutation (2 available); any Rasgrf1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:84625 )

• 15% decrease in total body weight when the mutant allele is transmitted by the male

postnatal growth retardation ( J:84625 )

• observed when mutant allele is transmitted by the male

cellular

maternal imprinting ( J:84625 )

• growth retardation and decreased body size when the mutant allele is transmitted by the male

Allelic Composition	Rasgrf1^tm3.1Pds/Rasgrf1⁺
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1^tm3.1Pds mutation (0 available); any Rasgrf1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal imprinting ( J:85825 )

• when the allele is inherited paternally, maternal silencing of wild-type allele is de-repressed

paternal imprinting ( J:85825 )

Allelic Composition	Meox2^tm1(cre)Sor/Meox2⁺ Rasgrf1^tm4.1Pds/Rasgrf1⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Rasgrf1^tm4.1Pds mutation (0 available); any Rasgrf1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:117666 )

N	• loss of paternal repeats does not affect expression of Rasgrf1 in neonatal brain • loss of paternal repeats at E5.5 in the epiblast does not result in changes to methylation state of the paternal allele, in contrast with deletion earlier in development

Allelic Composition	Rasgrf1^tm4.1Pds/Rasgrf1⁺ Tg(Zp3-cre)3Mrt/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1^tm4.1Pds mutation (0 available); any Rasgrf1 mutation (66 available)
Tg(Zp3-cre)3Mrt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:117666 )

• Rasgrf1 expression from paternal allele is silenced in neonatal brain

abnormal imprinting ( J:117666 )

• DNA from progeny has lost almost all differentially methylated domain (DMD) methylation from the paternal allele

• methylation on floxed allele cannot be maintained upon cre-mediated recombination in zygote

Allelic Composition	Rasgrf1^tm4.1Pds/Rasgrf1⁺ Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1^tm4.1Pds mutation (0 available); any Rasgrf1 mutation (66 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:117666 )

N	• loss of paternal repeats does not affect expression of Rasgrf1 in neonatal brain • loss of paternal repeats at E11 in the central nervous system does not result in changes to methylation state of the paternal allele, in contrast with deletion earlier in development

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