Phenotypes associated with this allele

• Allele Symbol: Tyrp1⁺
• Allele Name: wild type
• Allele ID: MGI:2435437
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tyrp1^B-w/Tyrp1^+	involves: 101/Rl * C3H/Rl	MGI:3771331
ht2	Tyrp1^B-lt/Tyrp1^+	involves: C58	MGI:3664744
ht3	Tyrp1^B-lt/Tyrp1^+	Not Specified	MGI:3687173
cx4	a/a Myo5a^d/Myo5a^+ Oca2^p/Oca2^+ Tyrp1^B-lt/Tyrp1^+	involves: C58 * CT/Ch	MGI:3795191
cx5	a/a Tyrp1^B-lt/Tyrp1^+	Not Specified	MGI:3795185
cx6	A/? Lyst^bg/Lyst^bg Tyrp1^+/?	Not Specified	MGI:4453314

Genotype
MGI:3771331

ht1

• Allelic Composition: Tyrp1^B-w/Tyrp1⁺
• Genetic Background: involves: 101/Rl * C3H/Rl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

diluted coat color ( J:13492 , J:18590 )

• pigment reduction at base of the hair (J:13492)

• the hair is almost black except for the extreme base which is light (J:13492)

• pigment loss is due to premature melanocyte death (J:18590)

integument

diluted coat color ( J:13492 , J:18590 )

• pigment reduction at base of the hair (J:13492)

• the hair is almost black except for the extreme base which is light (J:13492)

• pigment loss is due to premature melanocyte death (J:18590)

Genotype
MGI:3664744

ht2

• Allelic Composition: Tyrp1^B-lt/Tyrp1⁺
• Genetic Background: involves: C58

pigmentation

abnormal coat/hair pigmentation ( J:13061 )

diluted coat color ( J:13061 )

• the majority of each hair from tip down is pigmented, the lower part is less pigmented appearing gray

• mice are lighter than wildtype nonagouti mice but darker than homozygotes

integument

abnormal coat/hair pigmentation ( J:13061 )

diluted coat color ( J:13061 )

• the majority of each hair from tip down is pigmented, the lower part is less pigmented appearing gray

• mice are lighter than wildtype nonagouti mice but darker than homozygotes

Genotype
MGI:3687173

ht3

• Allelic Composition: Tyrp1^B-lt/Tyrp1⁺
• Genetic Background: Not Specified

hearing/vestibular/ear

abnormal ear morphology ( J:16249 )

abnormal inner ear morphology ( J:16249 )

abnormal stria vascularis morphology ( J:16249 )

abnormal ear physiology ( J:16249 )

abnormal hearing physiology ( J:16249 )

decreased endocochlear potential ( J:16249 )

• potential is reduced in 30% of mice as mice age

• reduction in potential is correlated with appearance of abundant pigment clumps in the stria vascularis

pigmentation

abnormal coat/hair pigmentation ( J:16249 )

• coat pigment is reduced with age

integument

abnormal coat/hair pigmentation ( J:16249 )

• coat pigment is reduced with age

Genotype
MGI:3795191

cx4

• Allelic Composition: a/a; Myo5a^d/Myo5a⁺; Oca2^p/Oca2⁺; Tyrp1^B-lt/Tyrp1⁺
• Genetic Background: involves: C58 * CT/Ch

pigmentation

diluted coat color ( J:13094 )

• dark sepia in color

• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment

integument

diluted coat color ( J:13094 )

• dark sepia in color

• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment

Genotype
MGI:3795185

cx5

• Allelic Composition: a/a; Tyrp1^B-lt/Tyrp1⁺
• Genetic Background: Not Specified

pigmentation

abnormal dorsoventral coat patterning ( J:13094 )

• the ventral hairs are substantially less pigmented than those of the dorsum

abnormal hair shaft melanin granule morphology ( J:13094 )

• large clumps of pigment are found in hair and vibrissae, but less frequently than in homozygotes

abnormal hair shaft melanin granule distribution ( J:13094 )

reduced hair shaft melanin granule number ( J:13094 )

• fewer pigment granules per septum in proceeding from tip to base of the hair, but more pigment granules than in homozygotes

integument

abnormal dorsoventral coat patterning ( J:13094 )

• the ventral hairs are substantially less pigmented than those of the dorsum

abnormal hair shaft melanin granule morphology ( J:13094 )

• large clumps of pigment are found in hair and vibrissae, but less frequently than in homozygotes

abnormal hair shaft melanin granule distribution ( J:13094 )

reduced hair shaft melanin granule number ( J:13094 )

• fewer pigment granules per septum in proceeding from tip to base of the hair, but more pigment granules than in homozygotes

Genotype
MGI:4453314

cx6

• Allelic Composition: A/?; Lyst^bg/Lyst^bg; Tyrp1⁺/?
• Genetic Background: Not Specified

pigmentation

decreased ear pigmentation ( J:29744 )

• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls

diluted coat color ( J:29744 )

• on an agouti black (A-B-) background, mice exhibit a lighter coat color than wild-type controls, particularly at the base of the hairs

• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice

irregular coat pigmentation ( J:29744 )

• on an agouti black (A-B-) background, mutant dorsal hairs have a yellow subterminal band, a dark grey middle portion, and usually a very light grey base

• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice

decreased tail pigmentation ( J:29744 )

• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls

abnormal eye pigmentation ( J:29744 )

• on an agouti black (A-B-) background, the eye pigmentation of mice is only slight at birth but varies from ruby to almost black in adults

vision/eye

abnormal eye pigmentation ( J:29744 )

• on an agouti black (A-B-) background, the eye pigmentation of mice is only slight at birth but varies from ruby to almost black in adults

limbs/digits/tail

decreased tail pigmentation ( J:29744 )

• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls

craniofacial

decreased ear pigmentation ( J:29744 )

• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls

hearing/vestibular/ear

decreased ear pigmentation ( J:29744 )

• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls

integument

decreased ear pigmentation ( J:29744 )

• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls

diluted coat color ( J:29744 )

• on an agouti black (A-B-) background, mice exhibit a lighter coat color than wild-type controls, particularly at the base of the hairs

• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice

irregular coat pigmentation ( J:29744 )

• on an agouti black (A-B-) background, mutant dorsal hairs have a yellow subterminal band, a dark grey middle portion, and usually a very light grey base

• basal dilution is first noted at ~15 days of age, is somewhat variable, and tends to become darker in older mice

decreased tail pigmentation ( J:29744 )

• on an agouti black (A-B-) background, mice exhibit reduced tail pigmentation relative to wild-type controls

growth/size/body

decreased ear pigmentation ( J:29744 )

• on an agouti black (A-B-) background, mice exhibit reduced ear pigmentation relative to wild-type controls