All Phenotypes Tfap2b<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tfap2b⁺
wild type
MGI:2435284

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tfap2b^em1Sleep/Tfap2b⁺	C57BL/6J-Tfap2b^em1Sleep	MGI:7627365
ht2	Tfap2b^em2Sleep/Tfap2b⁺	C57BL/6J-Tfap2b^em2Sleep	MGI:7627368
ht3	Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b⁺	C57BL/6N-Tfap2b^{tm1b(EUCOMM)Wtsi}/Ieg	MGI:6263672
ht4	Tfap2b^tm1Rbu/Tfap2b⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5292664
ht5	Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b⁺	involves: C57BL/6N * DBA/2	MGI:7627369

Allelic Composition	Tfap2b^em1Sleep/Tfap2b⁺
Genetic Background	C57BL/6J-Tfap2b^em1Sleep

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2b^em1Sleep mutation (0 available); any Tfap2b mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal circadian sleep/wake cycle ( J:297685 )

• increased time spent in wakefulness during dark phase

abnormal non-rapid eye movement sleep pattern ( J:297685 )

• reduced total time spent in NREM sleep

• reduced number of NREM sleep episodes

Allelic Composition	Tfap2b^em2Sleep/Tfap2b⁺
Genetic Background	C57BL/6J-Tfap2b^em2Sleep

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2b^em2Sleep mutation (0 available); any Tfap2b mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:297685 )

N	• normal total time spent in wakefulness, NREM sleep or REM sleep • normal number of wakefulness, NREM or REM sleep episodes

abnormal circadian sleep/wake cycle ( J:297685 )

• increased number of wakefulness, NREM sleep or REM sleep episodes in light phase

• normal total time spent in wakefulness, NREM sleep or REM sleep

abnormal non-rapid eye movement sleep pattern ( J:297685 )

• increased number of NREM sleep episodes in light phase

• decreased length of NREM sleep episodes

increased frequency of paradoxical sleep ( J:297685 )

• increased number of REM sleep episodes during light phase

Allelic Composition	Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b⁺
Genetic Background	C57BL/6N-Tfap2b^{tm1b(EUCOMM)Wtsi}/Ieg
Cell Lines	EPD0764_4_A09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2b^{tm1b(EUCOMM)Wtsi} mutation (1 available); any Tfap2b mutation (32 available)

Data Sources

IMPC Data for Tfap2b

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased grip strength ( J:211773 )

IMPC - HMGU

nervous system

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

vision/eye

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

iris synechia ( J:211773 )

IMPC - HMGU

Allelic Composition	Tfap2b^tm1Rbu/Tfap2b⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2b^tm1Rbu mutation (0 available); any Tfap2b mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

patent ductus arteriosus ( J:175832 )

• in 1 of 8 mice at 2 h post birth

limbs/digits/tail

postaxial polydactyly ( J:175832 )

• an additional finger-like structure (with a single phalange and no nail) grows out laterally from the 5th finger on the forelimbs of 18.2% of mice

cellular

patent ductus arteriosus ( J:175832 )

• in 1 of 8 mice at 2 h post birth

Allelic Composition	Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b⁺
Genetic Background	involves: C57BL/6N * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2b^{tm1b(EUCOMM)Wtsi} mutation (1 available); any Tfap2b mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:297685 )

N	• normal total time spent in wakefulness, NREM sleep or REM sleep • normal number of wakefulness and NREM sleep episodes

abnormal circadian sleep/wake cycle ( J:297685 )

• increased wakefulness in dark phase

• normal total time spent in REM sleep across light and dark phases

• normal NREM sleep during dark phase

abnormal non-rapid eye movement sleep pattern ( J:297685 )

• reduced NREM sleep during light phase

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