All Phenotypes Ctbp2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ctbp2⁺
wild type
MGI:2435160

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ctbp2^em1(IMPC)Bay/Ctbp2⁺	C57BL/6N-Ctbp2^em1(IMPC)Bay/BayMmucd	MGI:7316976
cx2	Ctbp1^tm1Sor/Ctbp1⁺ Ctbp2^{Gt(ROSA61)Sor}/Ctbp2⁺	involves: 129S4/SvJaeSor	MGI:3696582
cx3	Ctbp1^tm1Sor/Ctbp1^tm1Sor Ctbp2^{Gt(ROSA61)Sor}/Ctbp2⁺	involves: 129S4/SvJaeSor	MGI:3696583

Allelic Composition	Ctbp2^em1(IMPC)Bay/Ctbp2⁺
Genetic Background	C57BL/6N-Ctbp2^em1(IMPC)Bay/BayMmucd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctbp2^em1(IMPC)Bay mutation (1 available); any Ctbp2 mutation (572 available)

Data Sources

IMPC Data for Ctbp2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - BCM

Allelic Composition	Ctbp1^tm1Sor/Ctbp1⁺ Ctbp2^{Gt(ROSA61)Sor}/Ctbp2⁺
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctbp1^tm1Sor mutation (1 available); any Ctbp1 mutation (38 available)
Ctbp2^{Gt(ROSA61)Sor} mutation (1 available); any Ctbp2 mutation (572 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:77905 )

• about 26% of homozygotes die before 20 days of age

growth/size/body

decreased body size ( J:77905 )

• smaller than wild-type controls

Allelic Composition	Ctbp1^tm1Sor/Ctbp1^tm1Sor Ctbp2^{Gt(ROSA61)Sor}/Ctbp2⁺
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:77905 )

• die between E15.5 and E18.5

growth/size/body

decreased embryo size ( J:77905 )

• embryos small

cardiovascular system

hemorrhage ( J:77905 )

• extensive hemorrhage in embryos

skeleton

abnormal rib morphology ( J:77905 )

abnormal spine curvature ( J:77905 )

abnormal vertebrae development ( J:77905 )

muscle

abnormal muscle development ( J:77905 )

abnormal diaphragm morphology ( J:77905 )

• lacks myofibers

embryo

decreased embryo size ( J:77905 )

• embryos small

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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