Phenotypes associated with this allele

• Allele Symbol: Eomes⁺
• Allele Name: wild type
• Allele ID: MGI:2435157
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Eomes^tm1b(EUCOMM)Wtsi/Eomes^+	C57BL/6N-Eomes^tm1b(EUCOMM)Wtsi/H	MGI:5757047
ht2	Eomes^tm1.1(cre/ERT2)Sjar/Eomes^+	involves: 129S/SvEv	MGI:5499789
ht3	Eomes^tm1Apr/Eomes^+	involves: C57BL/6	MGI:3687958
cn4	Eomes^tm1Rob/Eomes^+ Nodal^tm1Rob/Nodal^+ Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129S/SvEv * C57BL/6 * CBA	MGI:3775737
cx5	Eomes^tm1.1Rob/Eomes^+ Wnt3^tm1Brd/Wnt3^+	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3775738
cx6	Eomes^tm1.1Rob/Eomes^+ Nodal^tm1Rob/Nodal^+	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3775732
cx7	Eomes^tm1.1Rob/Eomes^+ Nodal^tm4Rob/Nodal^tm4Rob	involves: 129S/SvEv * C57BL/6 * CBA	MGI:3775739
cx8	Eomes^tm1Apr/Eomes^+ Tbx21^tm1Srnr/Tbx21^tm1Srnr	involves: C57BL/6	MGI:3687959

Genotype
MGI:5757047

ht1

• Allelic Composition: Eomes^{tm1b(EUCOMM)Wtsi}/Eomes⁺
• Genetic Background: C57BL/6N-Eomes^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0809_2_G05

Data Sources

IMPC Data for Eomes

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - HAR

growth/size/body

decreased lean body mass ( J:211773 )

♂

IMPC - HAR

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

♂

IMPC - HAR

skeleton

decreased bone mineral content ( J:211773 )

IMPC - HAR

Genotype
MGI:5499789

ht2

• Allelic Composition: Eomes^{tm1.1(cre/ERT2)Sjar}/Eomes⁺
• Genetic Background: involves: 129S/SvEv

normal phenotype

no abnormal phenotype detected ( J:198846 )

• mice are viable, fertile and show no obvious abnormalities

Genotype
MGI:3687958

ht3

• Allelic Composition: Eomes^tm1Apr/Eomes⁺
• Genetic Background: involves: C57BL/6

immune system

decreased NK cell number ( J:112679 )

• lymphoid tissues considerably depleted of natural killer cells

decreased memory T cell number ( J:112679 )

• depleted CD8+ memory T cells

hematopoietic system

decreased NK cell number ( J:112679 )

• lymphoid tissues considerably depleted of natural killer cells

decreased memory T cell number ( J:112679 )

• depleted CD8+ memory T cells

Genotype
MGI:3775737

cn4

• Allelic Composition: Eomes^tm1Rob/Eomes⁺; Nodal^tm1Rob/Nodal⁺; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

mortality/aging

prenatal lethality ( J:131055 )

• severely affected embryos are not recovered

embryo

rostral body truncation ( J:131055 )

• embryos with anterior axis truncations are recovered at low frequency

Genotype
MGI:3775738

cx5

• Allelic Composition: Eomes^tm1.1Rob/Eomes⁺; Wnt3^tm1Brd/Wnt3⁺
• Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

normal phenotype

no abnormal phenotype detected ( J:131055 )

• no phenotypic abnormalities are observed at E9.5

Genotype
MGI:3775732

cx6

• Allelic Composition: Eomes^tm1.1Rob/Eomes⁺; Nodal^tm1Rob/Nodal⁺
• Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

embryo

abnormal anterior visceral endoderm cell migration ( J:131055 )

• AVE is correctly induced but fails to migrate anteriorly

abnormal developmental patterning ( J:131055 )

• heart patterning abnormalities are observed by E9.5 due to loss of midline structures

abnormal germ layer development ( J:131055 )

• embryos lack visible germ layers

abnormal left-right axis patterning ( J:131055 )

• left-right patterning abnormalities are observed by E9.5 due to loss of midline structures

abnormal rostral-caudal patterning of the somites ( J:131055 )

• floor plate expansion results in increased spacing between somite rows at E9.5

rostral body truncation ( J:131055 )

• by E9.5, mutants lack head structures rostral to the otic placodes

rostral-caudal axis duplication ( J:131055 )

• in the most severely affected embryos, relatively complete duplications of the posterior body axis are observed, including extra somite rows

enlarged floor plate ( J:131055 )

• node abnormalities result in expansion of the floor plate of the neural tube

abnormal notochord morphology ( J:131055 )

• node duplications are accompanied by formation of an accessory notochord

abnormal primitive node morphology ( J:131055 )

• at E8.5, development of the node is severely disturbed in a subset of mutants

• complete node duplications are observed in some mutants

failure of primitive streak formation ( J:131055 )

• the most severely affected double heterozygotes show abnormalities around E7 and fail to form a primitive streak

increased somite number ( J:131055 )

• addition rows of somites are observed in the most severely affected embryos

disorganized embryonic tissue ( J:131055 )

• by late gastrulation stages, embryos are grossly disorganized

embryonic-extraembryonic boundary constriction ( J:131055 )

• the most severely affected embryos develop pronounced constrictions between the embryonic and extraembryonic regions of the conceptus

abnormal amniotic cavity morphology ( J:131055 )

• embryos frequently show tissue accumulation within the amniotic cavity

nervous system

enlarged floor plate ( J:131055 )

• node abnormalities result in expansion of the floor plate of the neural tube

cellular

abnormal anterior visceral endoderm cell migration ( J:131055 )

• AVE is correctly induced but fails to migrate anteriorly

Genotype
MGI:3775739

cx7

• Allelic Composition: Eomes^tm1.1Rob/Eomes⁺; Nodal^tm4Rob/Nodal^tm4Rob
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

normal phenotype

no abnormal phenotype detected ( J:131055 )

• normal Mendelian numbers are recovered during embryogenesis

Genotype
MGI:3687959

cx8

• Allelic Composition: Eomes^tm1Apr/Eomes⁺; Tbx21^tm1Srnr/Tbx21^tm1Srnr
• Genetic Background: involves: C57BL/6

immune system

decreased NK cell number ( J:112679 )

• partial loss of natural killer cells

decreased NK T cell number ( J:112679 )

• lymphoid tissues considerably depleted of NK-T cells

decreased memory T cell number ( J:112679 )

• depleted CD8+ memory T cells

decreased interferon-gamma secretion ( J:112679 )

• defective Ifng production by CD8+ cells in vitro

hematopoietic system

decreased NK cell number ( J:112679 )

• partial loss of natural killer cells

decreased NK T cell number ( J:112679 )

• lymphoid tissues considerably depleted of NK-T cells

decreased memory T cell number ( J:112679 )

• depleted CD8+ memory T cells