All Phenotypes Tcf7l2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tcf7l2⁺
wild type
MGI:2435095

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tcf7l2^{tm1a(EUCOMM)Wtsi}/Tcf7l2⁺	C57BL/6N-Tcf7l2^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5706108
ht2	Tcf7l2^{tm1a(EUCOMM)Wtsi}/Tcf7l2⁺	C57BL/6-Tcf7l2^{tm1a(EUCOMM)Wtsi}	MGI:5449730
ht3	Tcf7l2^em1Nobr/Tcf7l2⁺	involves: CD-1	MGI:5294419
ht4	Tcf7l2^em2Nobr/Tcf7l2⁺	involves: CD-1	MGI:5294421
cn5	Tcf7l2^{tm3.1(cre/ERT2)Mrc}/Tcf7l2⁺ Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5141595
cx6	Apc^Min/Apc⁺ Tcf7l2^{tm1.1(EGFP/cre)Mrc}/Tcf7l2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:4946925
cx7	Apc^Min/Apc⁺ Tcf7l2^tm2.2Mrc/Tcf7l2⁺	involves: C57BL/6J	MGI:4946927

Allelic Composition	Tcf7l2^{tm1a(EUCOMM)Wtsi}/Tcf7l2⁺
Genetic Background	C57BL/6N-Tcf7l2^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0157_5_B10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l2^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Tcf7l2 mutation (58 available)

Data Sources

IMPC Data for Tcf7l2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - WTSI

growth/size/body

increased lean body mass ( J:211773 )

IMPC - WTSI

hematopoietic system

increased red blood cell distribution width ( J:211773 )

IMPC - WTSI

increased mean platelet volume ( J:211773 )

IMPC - WTSI

skeleton

increased bone mineral content ( J:211773 )

IMPC - WTSI

increased bone mineral density ( J:211773 )

IMPC - WTSI

Allelic Composition	Tcf7l2^{tm1a(EUCOMM)Wtsi}/Tcf7l2⁺
Genetic Background	C57BL/6-Tcf7l2^{tm1a(EUCOMM)Wtsi}
Cell Lines	EPD0157_5_B10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l2^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Tcf7l2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:190447 )

• increase in basal hepatic glucose production in hyperinsulinemic-euglycemic clamp studies

• despite changes in glucose levels, no abnormalities in insulin signaling or insulin levels are detected

increased circulating glucose level ( J:190447 )

• under fasting and feeding conditions

impaired glucose tolerance ( J:190447 )

abnormal response/metabolism to endogenous compounds ( J:190447 )

• display pyruvate intolerance that is accompanied with increased hepatic expression of gluconeogenic genes

liver/biliary system

abnormal hepatocyte physiology ( J:190447 )

• increase in basal hepatic glucose production in hyperinsulinemic-euglycemic clamp studies

Allelic Composition	Tcf7l2^em1Nobr/Tcf7l2⁺
Genetic Background	involves: CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l2^em1Nobr mutation (0 available); any Tcf7l2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:175874 )

N	• mice exhibit normal energy expenditure

decreased circulating glucose level ( J:175874 )

• in fasting mice fed a high-fat diet

hypoglycemia ( J:175874 )

• intermediate at birth

decreased circulating insulin level ( J:175874 )

• in fasting mice fed a high-fat diet

improved glucose tolerance ( J:175874 )

• on standard chow or when fed a high-fat diet

behavior/neurological

polyphagia ( J:175874 )

decreased locomotor activity ( J:175874 )

growth/size/body

decreased lean body mass ( J:175874 )

decreased body weight ( J:175874 )

• at 1 to 6 weeks of age

adipose tissue

decreased total body fat amount ( J:175874 )

Allelic Composition	Tcf7l2^em2Nobr/Tcf7l2⁺
Genetic Background	involves: CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l2^em2Nobr mutation (0 available); any Tcf7l2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:175874 )

N	• mice exhibit normal energy expenditure

decreased circulating glucose level ( J:175874 )

• in fasting mice fed a high-fat diet

hypoglycemia ( J:175874 )

• intermediate at birth

decreased circulating insulin level ( J:175874 )

• in fasting mice fed a high-fat diet

improved glucose tolerance ( J:175874 )

• on standard chow or when fed a high-fat diet

behavior/neurological

polyphagia ( J:175874 )

decreased locomotor activity ( J:175874 )

growth/size/body

decreased lean body mass ( J:175874 )

decreased body weight ( J:175874 )

• at 1 to 6 weeks of age

adipose tissue

decreased total body fat amount ( J:175874 )

Allelic Composition	Tcf7l2^{tm3.1(cre/ERT2)Mrc}/Tcf7l2⁺ Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(DTA)Mrc mutation (1 available); any Gt(ROSA)26Sor mutation (1243 available)
Tcf7l2^{tm3.1(cre/ERT2)Mrc} mutation (1 available); any Tcf7l2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle morphology ( J:174914 )

• 42% reduction in muscle connective tissue fibroblasts after 5 doses of tamoxifen

decreased skeletal muscle satellite cell number ( J:174914 )

• ablation of fibroblasts leads to 51% reduction in muscle satellite cells 5 days post injury

abnormal muscle regeneration ( J:174914 )

• at 3 days post injury fibroblasts are reduced 19% but myofiber regeneration is increased 5 fold

• leads to depletion of satellite cell pool and reduction in regenerating myofibers at 5 days

• tibialis anterior muscle is regenerated at 28 days after injury but somewhat smaller in cross-sectional area

• satellite cell numbers have recovered after 28 days

• smaller diameter of regenerated myofibers

• muscle size differences are no longer significant at 56 days after injury

Allelic Composition	Apc^Min/Apc⁺ Tcf7l2^{tm1.1(EGFP/cre)Mrc}/Tcf7l2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (155 available)
Tcf7l2^{tm1.1(EGFP/cre)Mrc} mutation (1 available); any Tcf7l2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:170088 )

• mice develop colorectal tubular adenomas unlike Apc^min heterozygotes

digestive/alimentary system

increased intestinal adenoma incidence ( J:170088 )

• mice develop colorectal tubular adenomas unlike Apc^min heterozygotes

Allelic Composition	Apc^Min/Apc⁺ Tcf7l2^tm2.2Mrc/Tcf7l2⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (155 available)
Tcf7l2^tm2.2Mrc mutation (0 available); any Tcf7l2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:170088 )

• mice develop colorectal tubular adenomas unlike Apc^min heterozygotes

digestive/alimentary system

increased intestinal adenoma incidence ( J:170088 )

• mice develop colorectal tubular adenomas unlike Apc^min heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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