Tcf7l2^{tm3.1(cre/ERT2)Mrc}
Targeted Allele Detail

Summary

• Symbol: Tcf7l2^{tm3.1(cre/ERT2)Mrc}
• Name: transcription factor 7 like 2, T cell specific, HMG box; targeted mutation 3.1, Mario R Capecchi
• MGI ID: MGI:5141491
• Synonyms: Tcf4^CreERT2
• Gene: Tcf7l2 Location: Chr19:55730252-55922086 bp, + strand Genetic Position: Chr19, 51.59 cM
• Alliance: Tcf7l2^{tm3.1(cre/ERT2)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174914
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Tcf7l2^{tm3.1(cre/ERT2)Mrc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tcf7l2 (MGI:1202879)

• Mutation details: The translated part of exon 1 was replaced by a cre/ERT2 cassette and a GCSF polyA signal. An FRT-flanked neomycin resistance (neo) cassette was inserted downstream of the creERT2 fusion gene. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:174914)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tcf7l2 (mouse) Summary of all recombinase alleles driven by Tcf7l2. Comparative matrix view of recombinase activities Alliance mouse Tcf7l2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tcf7l2 Mutation: 56 strains or lines available

Notes

ES cell line = R1-45, established from (129X1/SvJ x 129S1/Sv)F1-Kitl+

References

• Original: J:174914 Murphy MM, et al., Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration. Development. 2011 Sep;138(17):3625-37
• All: 1 reference(s)