All Phenotypes Dsg2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dsg2⁺
wild type
MGI:2435082

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dsg2^tm1Leu/Dsg2⁺	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	MGI:3611339
ht2	Dsg2^em1Spin/Dsg2⁺	involves: C57BL/6J	MGI:7571249
ht3	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺	involves: C57BL/6J * C57BL/6N	MGI:6501758
cx4	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺ Gsk3b^tm1Dral/Gsk3b⁺	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	MGI:6501755
cx5	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺ Gsk3b^tm1Dral/Gsk3b^tm1Dral	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	MGI:6501756

Allelic Composition	Dsg2^tm1Leu/Dsg2⁺
Genetic Background	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg2^tm1Leu mutation (0 available); any Dsg2 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:102536 )

• fewer than expected heterozygotes are found at E5.0, E5.5 and E6.5 with the expected ratio found only at E3.5

• Background Sensitivity: backcrossing to C57BL/6 for multiple generations resulted in a increased frequency of survival heterozygotes, with the proportion of heterozygotes increasing from 25.56% in F1 mice to 46.67% in F10 mice; however backcrossinf to 129/Sv did not increase survival

Allelic Composition	Dsg2^em1Spin/Dsg2⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg2^em1Spin mutation (0 available); any Dsg2 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal intercalated disk morphology ( J:342765 )

• increased ICD volume in heart owing to increased width between cells

abnormal heart right ventricle wall morphology ( J:342765 )

• fibrotic and calcified areas in myocardium

cardiac fibrosis ( J:342765 )

decreased right ventricle systolic pressure ( J:342765 )

• reduced fractional shortening

irregular heartbeat ( J:342765 )

• right ventricular arrhythmia

ventricular premature beat ( J:342765 )

abnormal QRS complex ( J:342765 )

• increased QRS interval

decreased QRS amplitude ( J:342765 )

• decreased S peak amplitude

cellular

decreased keratinocyte adhesion ( J:342765 )

integument

decreased keratinocyte adhesion ( J:342765 )

muscle

abnormal intercalated disk morphology ( J:342765 )

• increased ICD volume in heart owing to increased width between cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
arrhythmogenic right ventricular cardiomyopathy		DOID:0050431	OMIM:PS107970	J:342765

Allelic Composition	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg2^{tm1d(EUCOMM)Wtsi} mutation (0 available); any Dsg2 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:235770 )

N	• mice show normal cardiac function and histology at rest

abnormal heart electrocardiography waveform feature ( J:235770 )

• mice show abnormal ECG readings in response to exercise

Allelic Composition	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺ Gsk3b^tm1Dral/Gsk3b⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsg2^{tm1d(EUCOMM)Wtsi} mutation (0 available); any Dsg2 mutation (79 available)
Gsk3b^tm1Dral mutation (1 available); any Gsk3b mutation (111 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart electrocardiography waveform feature ( J:235770 )

• mice exhibit nearly normal cardiac function at 16 weeks of age, although subtle ECG abnormalities are seen

prolonged PR interval ( J:235770 )

prolonged QRS complex duration ( J:235770 )

Allelic Composition	Dsg2^{tm1d(EUCOMM)Wtsi}/Dsg2⁺ Gsk3b^tm1Dral/Gsk3b^tm1Dral
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart electrocardiography waveform feature ( J:235770 )

prolonged PR interval ( J:235770 )

prolonged QRS complex duration ( J:235770 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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