Dsg2^tm1Leu
Targeted Allele Detail

Summary

• Symbol: Dsg2^tm1Leu
• Name: desmoglein 2; targeted mutation 1, Rudolf E Leube
• MGI ID: MGI:3609221
• Synonyms: Dsg2^-
• Gene: Dsg2 Location: Chr18:20691131-20737578 bp, + strand Genetic Position: Chr18, 11.42 cM
• Alliance: Dsg2^tm1Leu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102536
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace exons 7 and 8 with a lacZ and neo cassette. The putative transcript would have a dysfunctional aminoterminal fragment, terminating in the extracellular E2 domain at a position that corresponds to amino acid 229 of the human transcript. (J:102536)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dsg2 Mutation: 79 strains or lines available

References

• Original: J:102536 Eshkind L, et al., Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells. Eur J Cell Biol. 2002 Nov;81(11):592-8
• All: 2 reference(s)