About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lmx1b+
wild type
MGI:2434964
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Lmx1bIcst/Lmx1b+ involves: BALB/cAnN * C3H/HeN MGI:2686914
cx2
 		Lmx1atm1Ics/Lmx1atm1Ics
Lmx1btm1Rjo/Lmx1b+ 		involves: 129S7/SvEvBrd * C57BL/6J MGI:5287990
cx3
 		Lmx1atm1Ics/Lmx1a+
Lmx1btm1Rjo/Lmx1b+ 		involves: 129S7/SvEvBrd * C57BL/6J MGI:5287989


Genotype
MGI:2686914
ht1
Allelic
Composition		 Lmx1bIcst/Lmx1b+
Genetic
Background		 involves: BALB/cAnN * C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1bIcst mutation (2 available); any Lmx1b mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

vision/eye
cornea vascularization ( J:215517 )
• neovascularization
abnormal optic nerve morphology ( J:215517 )
• nerve damage with progressive loss of axons
abnormal iridocorneal angle ( J:215517 )
• closed or open but narrowed angle
abnormal iris morphology ( J:75964 , J:215517 )
• other iris abnormalities noted such as membrane, bands or ectropian uveae (J:75964)
• flattened endothelial cells migrate onto the anterior surface of the iris (J:215517)
irregularly shaped pupil ( J:75964 )
• incomplete penetrance, incidence noted in 53% of animals
anterior iris synechia ( J:75964 , J:215517 )
• described as iris corneal adhesion with incomplete penetrance, incidence noted in 32% of animals (J:75964)
abnormal cornea endothelium morphology ( J:75964 , J:215517 )
• proliferation of corneal endothelial cells was noted (J:75964)
cornea opacity ( J:75964 , J:215517 )
• described as corneal haze with incomplete penetrance, incidence noted in 51% of animals (J:75964)
macrophthalmia ( J:75964 )
• noted in older mice, possibly due to glaucoma
buphthalmos ( J:215517 )
• by 6-8 weeks of age
ocular hypertension ( J:215517 )
• elevated intraocular pressure in 35% of mice

cardiovascular system
cornea vascularization ( J:215517 )
• neovascularization

nervous system
abnormal optic nerve morphology ( J:215517 )
• nerve damage with progressive loss of axons

renal/urinary system




Genotype
MGI:5287990
cx2
Allelic
Composition		 Lmx1atm1Ics/Lmx1atm1Ics
Lmx1btm1Rjo/Lmx1b+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1atm1Ics mutation (0 available); any Lmx1a mutation (23 available)
Lmx1btm1Rjo mutation (0 available); any Lmx1b mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased dopaminergic neuron number ( J:175535 )
• dramatic reduction in the number of dopaminergic neurons at E13.5 compared to embryos homozygous for the Lmx1a allele alone




Genotype
MGI:5287989
cx3
Allelic
Composition		 Lmx1atm1Ics/Lmx1a+
Lmx1btm1Rjo/Lmx1b+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1atm1Ics mutation (0 available); any Lmx1a mutation (23 available)
Lmx1btm1Rjo mutation (0 available); any Lmx1b mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased dopaminergic neuron number ( J:175535 )
• about a 20 - 25% reduction in the number of Nurr1- and Pitx3-expressing cells at E13.5 compared to wild-type or single heterozygous embryos




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/06/2026
MGI 6.29 		The Jackson Laboratory