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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Snai2+
wild type
MGI:2434681
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Snai2tm1.1(KOMP)Vlcg/Snai2+ C57BL/6N-Snai2tm1.1(KOMP)Vlcg/Ucd MGI:5797831
cx2
 		KitW-v/Kit+
Snai2tm2Grid/Snai2+ 		involves: 129S1/Sv * C57BL MGI:2652598
cx3
 		Snai2tm2Grid/Snai2+
Snai3tm1.2Jhws/Snai3tm1.2Jhws 		involves: 129/Sv * 129S1/Sv * C57BL/6 MGI:5620264


Genotype
MGI:5797831
ht1
Allelic
Composition		 Snai2tm1.1(KOMP)Vlcg/Snai2+
Genetic
Background		 C57BL/6N-Snai2tm1.1(KOMP)Vlcg/Ucd
Cell Lines 12328A-F6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai2tm1.1(KOMP)Vlcg mutation (1 available); any Snai2 mutation (33 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
enlarged heart ( J:211773 )
IMPC - UCD
hemorrhage ( J:211773 )
IMPC - UCD

embryo
spina bifida ( J:211773 )
IMPC - UCD

growth/size/body
enlarged heart ( J:211773 )
IMPC - UCD

nervous system
spina bifida ( J:211773 )
IMPC - UCD




Genotype
MGI:2652598
cx2
Allelic
Composition		 KitW-v/Kit+
Snai2tm2Grid/Snai2+
Genetic
Background		 involves: 129S1/Sv * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitW-v mutation (10 available); any Kit mutation (180 available)
Snai2tm2Grid mutation (1 available); any Snai2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
variable body spotting ( J:80529 )
• extensive white spotting of coat was noted from birth

integument
variable body spotting ( J:80529 )
• extensive white spotting of coat was noted from birth




Genotype
MGI:5620264
cx3
Allelic
Composition		 Snai2tm2Grid/Snai2+
Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic
Background		 involves: 129/Sv * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai2tm2Grid mutation (1 available); any Snai2 mutation (33 available)
Snai3tm1.2Jhws mutation (0 available); any Snai3 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal thymus cortex morphology ( J:204710 )
• altered thymic cortex organization
abnormal thymus medulla morphology ( J:204710 )
• altered thymic medulla organization

hematopoietic system
abnormal thymus cortex morphology ( J:204710 )
• altered thymic cortex organization
abnormal thymus medulla morphology ( J:204710 )
• altered thymic medulla organization
decreased B cell number ( J:204710 )
• reduced numbers of B220+ CD19+ cells in the blood
• phenotype is less severe than that observed in Snai3-/-Snai2-/- and Snai3-/+Snai2-/- mice
disorganized spleen B cell follicle ( J:204710 )
• follicle disorganization observed in spleens from 6 week old animals
• phenotype is less severe than that observed in Snai3-/-Snai2-/- mice

immune system
abnormal thymus cortex morphology ( J:204710 )
• altered thymic cortex organization
abnormal thymus medulla morphology ( J:204710 )
• altered thymic medulla organization
decreased B cell number ( J:204710 )
• reduced numbers of B220+ CD19+ cells in the blood
• phenotype is less severe than that observed in Snai3-/-Snai2-/- and Snai3-/+Snai2-/- mice
disorganized spleen B cell follicle ( J:204710 )
• follicle disorganization observed in spleens from 6 week old animals
• phenotype is less severe than that observed in Snai3-/-Snai2-/- mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory