All Phenotypes Ywhae<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ywhae⁺
wild type
MGI:2434580

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ywhae^tm1Awb/Ywhae⁺	involves: 129S6/SvEvTac	MGI:5512850
cn2	Ywhae^tm2.1Awb/Ywhae⁺ Ywhaz^{Gt(OST432062)Lex}/Ywhaz^{Gt(OST432062)Lex} H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Wnt1-GAL4)11Rth/0	involves: 129S6/SvEvTac * C57BL/6J	MGI:6267027
cn3	Ywhae^tm2.1Awb/Ywhae⁺ Ywhaz^{Gt(OST432062)Lex}/Ywhaz⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Wnt1-GAL4)11Rth/0	involves: 129S6/SvEvTac * C57BL/6J	MGI:6267030
cn4	Ywhae^tm2.1Awb/Ywhae⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Wnt1-GAL4)11Rth/0	involves: 129S6/SvEvTac * C57BL/6J	MGI:6267036
cx5	Pafah1b1^tm1Awb/Pafah1b1⁺ Ywhae^tm1Awb/Ywhae⁺	either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss)	MGI:2670767

Allelic Composition	Ywhae^tm1Awb/Ywhae⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ywhae^tm1Awb mutation (1 available); any Ywhae mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

thin ventricle myocardium compact layer ( J:192860 )

ventricular septal defect ( J:192860 )

• 20% of mutants exhibit ventricular septal defects at E14.5, but only 7% of mutants at E18.5, suggesting delayed maturation of the interventricular septum

abnormal heart left ventricle morphology ( J:192860 )

• thinner left ventricle

reproductive system

decreased litter size ( J:192860 )

• heterozygous females have small litters

muscle

thin ventricle myocardium compact layer ( J:192860 )

Allelic Composition	Ywhae^tm2.1Awb/Ywhae⁺ Ywhaz^{Gt(OST432062)Lex}/Ywhaz^{Gt(OST432062)Lex} H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Wnt1-GAL4)11Rth/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhae^tm2.1Awb mutation (1 available); any Ywhae mutation (60 available)
Ywhaz^{Gt(OST432062)Lex} mutation (3 available); any Ywhaz mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:242528 )

• although mice are able to survive to adulthood, their survival rate is lower than expected

premature death ( J:242528 )

growth/size/body

decreased body weight ( J:242528 )

• at P21, mice show significantly decreased body weight relative to control mice

pigmentation

belly spot ( J:242528 )

• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 1.09 cm²

• however, no white patches were observed on the tail and paws or any other region

integument

belly spot ( J:242528 )

• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 1.09 cm²

• however, no white patches were observed on the tail and paws or any other region

craniofacial

craniofacial phenotype ( J:242528 )

N	• at P21, mice exhibit no obvious defects in the craniofacial region

Allelic Composition	Ywhae^tm2.1Awb/Ywhae⁺ Ywhaz^{Gt(OST432062)Lex}/Ywhaz⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Wnt1-GAL4)11Rth/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belly spot ( J:242528 )

• at P21, 88.5 % of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.69 cm²

• however, no white patches were observed on the tail and paws or any other region

integument

belly spot ( J:242528 )

• at P21, 88.5 % of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.69 cm²

• however, no white patches were observed on the tail and paws or any other region

Allelic Composition	Ywhae^tm2.1Awb/Ywhae⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Wnt1-GAL4)11Rth/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:242528 )

N	• at P21, mice do not show white patches of fur on the ventral region of their torso or any other region

Allelic Composition	Pafah1b1^tm1Awb/Pafah1b1⁺ Ywhae^tm1Awb/Ywhae⁺
Genetic Background	either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pafah1b1^tm1Awb mutation (0 available); any Pafah1b1 mutation (158 available)
Ywhae^tm1Awb mutation (1 available); any Ywhae mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased neuronal migration ( J:84075 )

• neuronal migration distances in the cortex and in the hippocampus are shorter than in mice heterozygous for only one of these two loci

abnormal brain morphology ( J:84075 )

abnormal hippocampus morphology ( J:84075 )

• very severe abnormalities in pyramidal cell packing as compared to mice heterozygous at only one of these two loci

cellular

decreased neuronal migration ( J:84075 )

• neuronal migration distances in the cortex and in the hippocampus are shorter than in mice heterozygous for only one of these two loci

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
lissencephaly	DOID:0050453	OMIM:PS607432	J:84075
Miller-Dieker lissencephaly syndrome	DOID:0060469	OMIM:247200	J:84075

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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