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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctcf+
wild type
MGI:2434421
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ctcfem1Hyao/Ctcf+ C57BL/6N-Ctcfem1Hyao MGI:7664166
ht2
 		Ctcftm2.1Gal/Ctcf+ involves: 129P2/OlaHsd * C57BL/6 MGI:3829019
cn3
 		Ctcftm2Gal/Ctcf+
Tg(Lck-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3829017


Genotype
MGI:7664166
ht1
Allelic
Composition		 Ctcfem1Hyao/Ctcf+
Genetic
Background		 C57BL/6N-Ctcfem1Hyao
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctcfem1Hyao mutation (0 available); any Ctcf mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:350502 )
N
• normal behavior in open field, novel object recognition, three chamber, elevated plus maze, and Morris water maze tests
impaired exercise endurance ( J:350502 )
• reduced endurance in rotarod test

growth/size/body
thin body ( J:350502 )
• lean body at age 1 month

homeostasis/metabolism
impaired exercise endurance ( J:350502 )
• reduced endurance in rotarod test

mortality/aging
mortality/aging ( J:350502 )
N
• normal lifespan




Genotype
MGI:3829019
ht2
Allelic
Composition		 Ctcftm2.1Gal/Ctcf+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctcftm2.1Gal mutation (0 available); any Ctcf mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:143271 )
• fewer than expected mice survive to adulthood




Genotype
MGI:3829017
cn3
Allelic
Composition		 Ctcftm2Gal/Ctcf+
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctcftm2Gal mutation (0 available); any Ctcf mutation (78 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:143271 )
• modestly
decreased CD4-positive, alpha-beta T cell number ( J:143271 )
• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice
• however, the ratio of mature single positive cells to double positive cells is normal
decreased CD8-positive, alpha-beta T cell number ( J:143271 )
• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice
• however, the ratio of mature single positive cells to double positive cells is normal

hematopoietic system
thymus hypoplasia ( J:143271 )
• modestly
decreased CD4-positive, alpha-beta T cell number ( J:143271 )
• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice
• however, the ratio of mature single positive cells to double positive cells is normal
decreased CD8-positive, alpha-beta T cell number ( J:143271 )
• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice
• however, the ratio of mature single positive cells to double positive cells is normal

endocrine/exocrine glands
thymus hypoplasia ( J:143271 )
• modestly




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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory