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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smn1+
wild type
MGI:2434369
Summary 6 genotypes


Genotype
MGI:3721428
ht1
Allelic
Composition		 Smn1tm1.1Jme/Smn1+
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm1.1Jme mutation (1 available); any Smn1 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:61396 )
• gained weight normally and have remained indistinguishable from wild-type up to 12 months of age
• histological examination of skeletal muscle did not show any morphological changes




Genotype
MGI:3832214
cx2
Allelic
Composition		 Smn1tm1Msd/Smn1+
Tg(SMN2)11Tro/Tg(SMN2)11Tro
Genetic
Background		 B6.Cg-Smn1tm1Msd Tg(SMN2)11Tro
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm1Msd mutation (37 available); any Smn1 mutation (87 available)
Tg(SMN2)11Tro mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:144852 )
N
• homozygous mice do not show an spinal muscular atrophy (SMA)-like phenotype




Genotype
MGI:3832213
cx3
Allelic
Composition		 Smn1tm1Msd/Smn1+
Tg(SMN2)46Tro/Tg(SMN2)46Tro
Genetic
Background		 B6.Cg-Smn1tm1Msd Tg(SMN2)46Tro
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm1Msd mutation (37 available); any Smn1 mutation (87 available)
Tg(SMN2)46Tro mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system




Genotype
MGI:5484559
cx4
Allelic
Composition		 Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+
Smn1tm1Hung/Smn1+
Tg(SMN2)2Hung/0
Genetic
Background		 B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir mutation (0 available); any Gt(ROSA)26Sor mutation (1095 available)
Smn1tm1Hung mutation (4 available); any Smn1 mutation (87 available)
Tg(SMN2)2Hung mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal motor neuron morphology ( J:193844 )
• increased motor neuron size compared with Smn1tm1Hung/Smn1+ Tg(SMN2)2Hung mice
abnormal neuromuscular synapse morphology ( J:193844 )
• at P4 and P8, endplate size is increased compared to in Smn1tm1Hung/Smn1+ Tg(SMN2)2Hung mice
• at P1 and P4, endplates exhibit an increase in axon input compared with Smn1tm1Hung/Smn1+ Tg(SMN2)2Hung mice




Genotype
MGI:2451057
cx5
Allelic
Composition		 Gemin2tm1Msd/Gemin2+
Smn1tm1Msd/Smn1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gemin2tm1Msd mutation (0 available); any Gemin2 mutation (10 available)
Smn1tm1Msd mutation (37 available); any Smn1 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased motor neuron number ( J:81784 )
• number of lumbar motoneurons reduced by 34% at 5 months of age
• much less and non significant degeneration of facial motoneurons




Genotype
MGI:5286604
cx6
Allelic
Composition		 Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy
Smn1tm1Msd/Smn1+
Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb
Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy mutation (6 available); any Gt(ROSA)26Sor mutation (1095 available)
Smn1tm1Msd mutation (37 available); any Smn1 mutation (87 available)
Tg(SMN2)#Ahmb mutation (0 available)
Tg(SMN2*delta7)4299Ahmb mutation (13 available)
Tg(tetO-SMN2,-luc)#aAhmb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:174960 )
• only one mouse treated with doxycycline at P2 survived for 151 days
postnatal lethality, complete penetrance ( J:174960 )
• un-induced mice die on average at P14
• however, mice treated with doxycycline at E13 or at birth live for over 200 days

digestive/alimentary system
abnormal intestine morphology ( J:174960 )
• some doxycycline-treated mice exhibit impacted bowel and pockets of fluid and gas unlike control mice

growth/size/body
decreased body size ( J:174960 )
• doxcycline-treated mice are smaller than control mice

behavior/neurological
behavior/neurological phenotype ( J:174960 )
N
• doxycycline-treated mice exhibit normal motor function
decreased locomotor activity ( J:174960 )
• in doxcycline-treated mice close to death

hearing/vestibular/ear
abnormal ear morphology ( J:174960 )
• some doxycycline-treated mice exhibit ear necrosis compared with control mice

nervous system
nervous system phenotype ( J:174960 )
N
• doxycycline-treated mice exhibit normal endplates and miniature endplate currents and neuromuscular junctions




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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory