Tg(SMN2*delta7)4299Ahmb
Transgene Detail

Summary

• Symbol: Tg(SMN2*delta7)4299Ahmb
• Name: transgene insertion 4299, Arthur H M Burghes
• MGI ID: MGI:3056918
• Synonyms: SMNdelta7, Tg(SMN1*delta7)4299Ahmb
• Transgene: Tg(SMN2*delta7)4299Ahmb Location: unknown
• Alliance: Tg(SMN2*delta7)4299Ahmb page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SMN2*delta7)4299Ahmb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SMN2 (6607)

  Smn1	(MGI:109257)

• Mutation details: The transgene contains a human SMN2 promoter and a human SMN2 cDNA (SMNdelta7) that lacks exon 7. There are 14 copies of this allele integrated into the genome. (J:97103)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 13 strains available Cell Lines: 0 lines available

References

• Original: J:97103 Le TT, et al., SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN. Hum Mol Genet. 2005 Mar 15;14(6):845-57
• All: 116 reference(s)