Analysis Tools|
Allele Symbol Allele Name Allele ID |
Or10a4+ wild type MGI:2434235 |
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| Summary |
14 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutant glomeruli are ventral and anterior to endogenous P4 glomeruli
• number of glomeruli per half-bulb doubles, indicating formation of novel glomeruli
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• mutant axons do not reroute
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• axons expressing Olfr19 from the Olfr17 promoter are redirected about 2 microns posterior to the glomeruli normally targeted by Olfr17 expressing neurons
• axons expressing the mutant receptor are not directed anywhere near the glomeruli normally targeted by Olfr19 expressing neurons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• axons of olfactory neurons expressing the mutant allele display a diffuse distribution on the outer nerve layer of the olfactory bulb with very few entering the glomerular layer
• aberrant pattern apparent as early as E17
• number of axons expressing deletion declines from birth to 10 weeks of age when axon number is about 1% of control numbers
• similar results are seen in homozygous animals
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• axons of olfactory neurons expressing the mutant allele project to a single glomerulus posterior to those normally receiving Olfr17 axons and dorsal to the normal Olfr6 glomerulus
• similar results are seen in homozygous animals
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• examined only in chimeras
• axons of olfactory neurons expressing the mutant allele project more dorsally to glomeruli intermediate between those normally receiving Olfr17 axons and those receiving Olfr151 axons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• axons of olfactory neurons expressing the mutant allele project to glomeruli immediately adjacent to those for wild-type Olfr713 expressing axons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
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• no obvious Olfr17+ axonal convergence is seen in the olfactory bulb
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
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• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb
• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus
• administration of doxycycline for 3 weeks further restores Olfr17 neurons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decrease in the number of labeled sensory neurons in the olfactory bulb
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• decrease in the number of labeled sensory neurons in the olfactory bulb
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• decrease in the number of labeled sensory neurons in the olfactory bulb
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• decrease in the number of labeled sensory neurons in the olfactory bulb
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• decrease in the number of labeled sensory neurons in the olfactory bulb
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Impaired glomerular formation in Ttc8tm1Reed/Ttc8tm1Reed Or10a4tm1Mom/Or10a4+ neonatal pups
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• abnormal targeting of labeled olfactory sensory neuron axons is observed at P0
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• abnormal targeting of labeled olfactory sensory neuron axons is observed at P0
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Olfr17+ neurons fail to innervate glomeruli
• fewer Olfr17+ neurons are present (118+/-6 compared to 486+/-46 in wild-type mice)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• novel glomeruli form ventrally to endogenous P3 glomeruli, and are separated by 2-3 glomeruli; shift is not as greater as P4-P2 glomeruli shift relative toP4 glomeruli
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• mutant axons do not reroute to P3 glomeruli
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• two additional dorsal glomeruli are formed in olfactory bulb; one is close to P2 glomerulus and other apposes M50 glomerulus 1
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• a subpopulation of mutant axons reroutes to M50 glomeruli, but majority of axons form 2 extra glomeruli which are homogeneous; these subpopulations likely originate in different parts of the olfactory epithelium
• some mutant neurons are located ventrally (Z1 glomeruli) and others are distributed more dorsally (Z2 and Z3 glomeruli)
• some Olfr6tm1Mom axons project to the Z2 glomeruli but not the Z3 glomeruli
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following doxycycline treatment during gestation or post-weaning, synaptic release in Olfr17+ olfactory sensory neurons is inhibited
• following doxycycline treatment during gestation, targeting of Olfr17+ olfactory nerves fail to converge on the Olfr17+ glomeruli and the number of lacZ+ olfactory nerves decreases with time
• following doxycycline treatment post-weaning, Olfr17+ olfactory nerves migrate randomly within 2 days of induction and their numbers are reduced
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following doxycycline treatment during gestation, Oflr17+ olfactory nerve cells call to enter the olfactory bulb with only a few fibers crossing the cribriform plate that do not converge to form a single glomerulus but innervate a broad region o the ventral portion of the bulb
• following doxycycline treatment during gestation, the number of Oflr17+ olfactory nerves is decreased by 5-fold at P21
• after 40 days of doxycycline, Olfr17+ olfactory nerves no longer converge on a Oflr17+ glomerulus and few nerves stain positive for lacZ
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 01/13/2026 MGI 6.24 |
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