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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hdac1+
wild type
MGI:2434155
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Hdac1tm1b(EUCOMM)Wtsi/Hdac1+ C57BL/6N-Hdac1tm1b(EUCOMM)Wtsi/Ieg MGI:6262605
ht2
 		Hdac1tm1Sei/Hdac1+ either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6) MGI:3622927
cn3
 		Hdac1tm1.1Shmc/Hdac1+
Hdac2tm1.1Shmc/Hdac2tm1.1Shmc
Tg(Lck-cre)1Cwi/0 		involves: 129S7/SvEvBrd MGI:5485402


Genotype
MGI:6262605
ht1
Allelic
Composition		 Hdac1tm1b(EUCOMM)Wtsi/Hdac1+
Genetic
Background		 C57BL/6N-Hdac1tm1b(EUCOMM)Wtsi/Ieg
Cell Lines EPD0028_5_G01
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1b(EUCOMM)Wtsi mutation (1 available); any Hdac1 mutation (38 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

hematopoietic system




Genotype
MGI:3622927
ht2
Allelic
Composition		 Hdac1tm1Sei/Hdac1+
Genetic
Background		 either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1Sei mutation (0 available); any Hdac1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:76941 )
• lower than expected numbers of heterozygous births, but survivors exhibit normal fertility, viability and phenotypic appearance




Genotype
MGI:5485402
cn3
Allelic
Composition		 Hdac1tm1.1Shmc/Hdac1+
Hdac2tm1.1Shmc/Hdac2tm1.1Shmc
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Shmc mutation (0 available); any Hdac1 mutation (38 available)
Hdac2tm1.1Shmc mutation (0 available); any Hdac2 mutation (39 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:194769 )
N
• mice exhibit normal numbers of double negative, double positive, CD4 single positive and CD8 single positive T cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory