All Phenotypes Lrig1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lrig1⁺
wild type
MGI:2434014

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Scd1^tm2Ntam/Scd1^tm2Ntam Lrig1^{tm1.1(cre/ERT2)Rjc}/Lrig1⁺	B6.129(Cg)-Lrig1^{tm1.1(cre/ERT2)Rjc} Scd1^tm2Ntam	MGI:7287840
cn2	Apc^tm2.1Cip/Apc⁺ Lrig1^{tm1.1(cre/ERT2)Rjc}/Lrig1⁺	involves: 129 * 129P2/OlaHsd * C57BL/6	MGI:5432136
cx3	Lrig1^{Gt(GST4169C6)Lex}/Lrig1⁺ Lrig3^tm1.1Good/Lrig3^tm1.1Good	B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good	MGI:5551795

Allelic Composition	Scd1^tm2Ntam/Scd1^tm2Ntam Lrig1^{tm1.1(cre/ERT2)Rjc}/Lrig1⁺
Genetic Background	B6.129(Cg)-Lrig1^{tm1.1(cre/ERT2)Rjc} Scd1^tm2Ntam

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrig1^{tm1.1(cre/ERT2)Rjc} mutation (1 available); any Lrig1 mutation (49 available)
Scd1^tm2Ntam mutation (0 available); any Scd1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair shaft morphology ( J:325761 )

• decreased hair shaft

abnormal hair follicle matrix region morphology ( J:325761 )

• loss of matrix progenitors

decreased hair follicle number ( J:325761 )

hair follicle degeneration ( J:325761 )

abnormal dermis papillary layer morphology ( J:325761 )

• loss of dermal papilla cells

Allelic Composition	Apc^tm2.1Cip/Apc⁺ Lrig1^{tm1.1(cre/ERT2)Rjc}/Lrig1⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm2.1Cip mutation (2 available); any Apc mutation (154 available)
Lrig1^{tm1.1(cre/ERT2)Rjc} mutation (1 available); any Lrig1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:186084 )

• with tamoxifen treatement, colon tumors are observed by day 50 following Apc^fldeletion with cre induction (and stochastic loss of second Apc allele)

• by day 50 there are multiple distal colonic tumors with no proximal colon tumor burden; tumor phenotype is 100% penetrant

• largest tumors are found in distal colon, many having high grade dysplasia; highest tumor number is observed in jejunum

digestive/alimentary system

increased intestinal adenoma incidence ( J:186084 )

• with tamoxifen treatement, colon tumors are observed by day 50 following Apc^fldeletion with cre induction (and stochastic loss of second Apc allele)

• by day 50 there are multiple distal colonic tumors with no proximal colon tumor burden; tumor phenotype is 100% penetrant

• largest tumors are found in distal colon, many having high grade dysplasia; highest tumor number is observed in jejunum

Allelic Composition	Lrig1^{Gt(GST4169C6)Lex}/Lrig1⁺ Lrig3^tm1.1Good/Lrig3^tm1.1Good
Genetic Background	B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrig1^{Gt(GST4169C6)Lex} mutation (0 available); any Lrig1 mutation (49 available)
Lrig3^tm1.1Good mutation (0 available); any Lrig3 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal lateral semicircular canal morphology ( J:202451 )

• seen in 2 of 10 mice

• similar to Lrig3 single mutant mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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