Lrig1^{Gt(GST4169C6)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Lrig1^{Gt(GST4169C6)Lex}
• Name: leucine-rich repeats and immunoglobulin-like domains 1; gene trap GST4169C6, Lexicon Genetics
• MGI ID: MGI:5551790
• Gene: Lrig1 Location: Chr6:94581510-94677139 bp, - strand Genetic Position: Chr6, 43.15 cM
• Alliance: Lrig1^{Gt(GST4169C6)Lex} page

Mutation origin

• Mutant Cell Line: GST4169C6
• Germline Transmission: Earliest citation of germline transmission: J:202451
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: VICTR48 Vector Type: gene trap
• Mutation details: The gene trap vector inserted in intron 3 and is predicted to result in a protein fusion to the 3rd extracellular leucine rich repeat of the ectodomain. Western blot and immunoblot analysis indicated that protein levels are severely reduced in embryonic lysates from homozygous mice. (J:202451)

Expression

In Mice Carrying this Mutation:

25 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrig1 Mutation: 49 strains or lines available

References

• Original: J:202451 Del Rio T, et al., In vivo analysis of lrig genes reveals redundant and independent functions in the inner ear. PLoS Genet. 2013 Sep;9(9):e1003824
• All: 1 reference(s)