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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrig1Gt(GST4169C6)Lex
gene trap GST4169C6, Lexicon Genetics
MGI:5551790
Summary 5 genotypes


Genotype
MGI:5551792
hm1
Allelic
Composition		 Lrig1Gt(GST4169C6)Lex/Lrig1Gt(GST4169C6)Lex
Genetic
Background		 B6N.129-Lrig1Gt(GST4169C6)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrig1Gt(GST4169C6)Lex mutation (0 available); any Lrig1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:202451 )
N
• normal inner ear morphology at E14.5
abnormal auditory brainstem response waveform shape ( J:202451 )
• amplitude of the first wave is significantly diminished in response to a range of frequencies and sound intensities
increased or absent threshold for auditory brainstem response ( J:202451 )
• significantly elevated threshold in response to 11.3 and 16 kHz stimuli
increased or absent distortion product otoacoustic emission threshold ( J:202451 )
• significantly elevated threshold in response to 11.3 and 16 kHz stimuli




Genotype
MGI:5551808
cx2
Allelic
Composition		 Lrig1Gt(GST4169C6)Lex/Lrig1Gt(GST4169C6)Lex
Lrig2Gt(RST656)Byg/Lrig2Gt(RST656)Byg
Genetic
Background		 B6N.129-Lrig2Gt(RST656)Byg Lrig1Gt(GST4169C6)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrig1Gt(GST4169C6)Lex mutation (0 available); any Lrig1 mutation (49 available)
Lrig2Gt(RST656)Byg mutation (1 available); any Lrig2 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:202451 )
• very few mice survive to 6 weeks of age

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:202451 )
N
• normal ear development
abnormal auditory brainstem response waveform shape ( J:202451 )
• amplitude of the first wave is significantly diminished in response to a range of frequencies and sound intensities
• latencies are increased
• defects are more severe than in single mutants
increased or absent threshold for auditory brainstem response ( J:202451 )
• only respond to sounds greater than 55 dB across all frequencies
increased or absent distortion product otoacoustic emission threshold ( J:202451 )
• only respond to sounds greater than 55 dB across all frequencies

behavior/neurological
circling ( J:202451 )
• seen in half of surviving mice

growth/size/body
decreased body size ( J:202451 )
• runty during adolescence

nervous system
abnormal sensory neuron innervation pattern ( J:202451 )
• overall pattern of cochlear innervation is disrupted
• neurites are noticeably defasciculated and the gaps between the bundles are smaller and present only intermittently
• the inner spiral bundle is reduced
• efferent innervation of the cochlea is reduced




Genotype
MGI:5551809
cx3
Allelic
Composition		 Lrig1Gt(GST4169C6)Lex/Lrig1Gt(GST4169C6)Lex
Lrig2Gt(RST656)Byg/Lrig2+
Genetic
Background		 B6N.129-Lrig2Gt(RST656)Byg Lrig1Gt(GST4169C6)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrig1Gt(GST4169C6)Lex mutation (0 available); any Lrig1 mutation (49 available)
Lrig2Gt(RST656)Byg mutation (1 available); any Lrig2 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:202451 )
• only respond to sounds greater than 55 dB across all frequencies
increased or absent distortion product otoacoustic emission threshold ( J:202451 )
• only respond to sounds greater than 55 dB across all frequencies

nervous system
abnormal sensory neuron innervation pattern ( J:202451 )
• disruption of cochlear innervation is not as severe as in double homozygous mice




Genotype
MGI:5551795
cx4
Allelic
Composition		 Lrig1Gt(GST4169C6)Lex/Lrig1+
Lrig3tm1.1Good/Lrig3tm1.1Good
Genetic
Background		 B6N.Cg-Lrig1Gt(GST4169C6)Lex Lrig3tm1.1Good
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrig1Gt(GST4169C6)Lex mutation (0 available); any Lrig1 mutation (49 available)
Lrig3tm1.1Good mutation (0 available); any Lrig3 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal lateral semicircular canal morphology ( J:202451 )
• seen in 2 of 10 mice
• similar to Lrig3 single mutant mice




Genotype
MGI:5551793
cx5
Allelic
Composition		 Lrig1Gt(GST4169C6)Lex/Lrig1Gt(GST4169C6)Lex
Lrig3tm1.1Good/Lrig3tm1.1Good
Genetic
Background		 B6N.Cg-Lrig1Gt(GST4169C6)Lex Lrig3tm1.1Good
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrig1Gt(GST4169C6)Lex mutation (0 available); any Lrig1 mutation (49 available)
Lrig3tm1.1Good mutation (0 available); any Lrig3 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:202451 )
• die at or before birth

hearing/vestibular/ear
abnormal inner ear development ( J:202451 )
• more severely disrupted than in either single mutant
abnormal lateral semicircular canal morphology ( J:202451 )
• small and misshapen in 5 of 10 mice
abnormal otolith organ morphology ( J:202451 )
• saccule and utricle fail to separate in 10 of 10 mice

vision/eye

skeleton
abnormal skeleton morphology ( J:202451 )
• skeletal malformations




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory