Phenotypes associated with this allele

• Allele Symbol: Ifng⁺
• Allele Name: wild type
• Allele ID: MGI:2433938
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ifng^tm1.1(KOMP)Vlcg/Ifng^+	C57BL/6N-Ifng^tm1.1(KOMP)Vlcg/Ucd	MGI:6288518
cx2	Ifng^tm1Ts/Ifng^+ Socs1^tm1Wehi/Socs1^tm1Wehi	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6	MGI:4850158
cx3	Fas^lpr/Fas^lpr Ifng^tm1Ts/Ifng^+	MRL.Cg-Ifng^tm1Ts Fas^lpr	MGI:3801419

Genotype
MGI:6288518

ht1

• Allelic Composition: Ifng^{tm1.1(KOMP)Vlcg}/Ifng⁺
• Genetic Background: C57BL/6N-Ifng^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 10801A-D5

Data Sources

IMPC Data for Ifng

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased hematocrit ( J:211773 )

♂

IMPC - UCD

nervous system

decreased prepulse inhibition ( J:211773 )

♀

IMPC - UCD

respiratory system

abnormal lung morphology ( J:211773 )

♂

IMPC - UCD

Genotype
MGI:4850158

cx2

• Allelic Composition: Ifng^tm1Ts/Ifng⁺; Socs1^tm1Wehi/Socs1^tm1Wehi
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

mortality/aging

decreased survivor rate ( J:57474 )

• 8 of 12 mice died between 2 and 12 weeks of age, the remaining 4 survived

premature death ( J:57474 )

• 8 of 12 mice died between 2 and 12 weeks of age, the remaining 4 survived

Genotype
MGI:3801419

cx3

• Allelic Composition: Fas^lpr/Fas^lpr; Ifng^tm1Ts/Ifng⁺
• Genetic Background: MRL.Cg-Ifng^tm1Ts Fas^lpr

mortality/aging

premature death ( J:123834 )

• mice become moribund and are sacrificed at 4 months mutants posttransfer of Ifng wild-type F4/80+ macrophages at 2 months while all controls remain alive

immune system

abnormal macrophage chemotaxis ( J:123834 )

• macrophage accumulation is reduced compared to Fas^lpr homozygotes

increased autoantibody level ( J:123834 )

• mice develop glomerular autoantibody deposits, but do not develop glomerulonephritis

glomerulonephritis ( J:123834 )

• mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months develop diffuse proliferative glomerulonephritis by 6 months

renal/urinary system

abnormal renal glomerulus morphology ( J:123834 )

• glomeruli are hypercellular in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months

• glomerular damage is more severe in mice receiving cell transfer than in control mice not receiving transfers

abnormal glomerular capillary morphology ( J:123834 )

• thickening of capillary walls in glomeruli is observed in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months

increased mesangial cell number ( J:123834 )

• mesangial cells are increased in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months

glomerulonephritis ( J:123834 )

• mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months develop diffuse proliferative glomerulonephritis by 6 months

homeostasis/metabolism

increased blood urea nitrogen level ( J:123834 )

• BUN levels are elevated at time of death in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months

cardiovascular system

abnormal glomerular capillary morphology ( J:123834 )

• thickening of capillary walls in glomeruli is observed in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months

cellular

increased mesangial cell number ( J:123834 )

• mesangial cells are increased in mutants receiving adoptive transfer of Ifng wild-type F4/80+ macrophages at 2 months

abnormal macrophage chemotaxis ( J:123834 )

• macrophage accumulation is reduced compared to Fas^lpr homozygotes

hematopoietic system

abnormal macrophage chemotaxis ( J:123834 )

• macrophage accumulation is reduced compared to Fas^lpr homozygotes