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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dvl2+
wild type
MGI:2433683
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Dvl2tm1.2Wds/Dvl2+
Shroom3Gt(ROSA53)Sor/Shroom3+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA MGI:7560660
cx2
 		Dvl2tm1.2Wds/Dvl2+
Shroom3Gt(ROSA53)Sor/Shroom3Gt(ROSA53)Sor 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA MGI:7560662
cx3
 		Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2+ 		involves: 129S6/SvEvTac MGI:3608684
cx4
 		Dvl2tm1Awb/Dvl2+
Dvl3tm1Awb/Dvl3tm1Awb 		involves: 129S6/SvEvTac * Black Swiss MGI:3831931
cx5
 		Dvl2tm1Awb/Dvl2+
Dvl3tm1Awb/Dvl3+ 		involves: 129S6/SvEvTac * Black Swiss MGI:3831932


Genotype
MGI:7560660
cx1
Allelic
Composition		 Dvl2tm1.2Wds/Dvl2+
Shroom3Gt(ROSA53)Sor/Shroom3+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1.2Wds mutation (0 available); any Dvl2 mutation (33 available)
Shroom3Gt(ROSA53)Sor mutation (1 available); any Shroom3 mutation (206 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:293794 )
• at E14.5, one embryo shows planar cell polarity (PCP) associated cardiac defects, including DORV and membranous VSD
double outlet right ventricle ( J:293794 )
• at E14.5, one embryo shows DORV
perimembraneous ventricular septal defect ( J:293794 )
• at E14.5, one embryo shows a membranous VSD




Genotype
MGI:7560662
cx2
Allelic
Composition		 Dvl2tm1.2Wds/Dvl2+
Shroom3Gt(ROSA53)Sor/Shroom3Gt(ROSA53)Sor
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1.2Wds mutation (0 available); any Dvl2 mutation (33 available)
Shroom3Gt(ROSA53)Sor mutation (1 available); any Shroom3 mutation (206 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:293794 )
• when Shroom3Gt(ROSA53)Sor/Shroom3+; Dvl2tm1.2Wds/Dvl2+ are crossed to Shroom3Gt(ROSA53)Sor/Shroom3+; Dvl2tm1.2Wds/Dvl2tm1.2Wds, no male Shroom3Gt(ROSA53)SorShroom3Gt(ROSA53)Sor;Dvl2tm1.2Wds/Dvl2+ mice are recovered at E14.5




Genotype
MGI:3608684
cx3
Allelic
Composition		 Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (31 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:100861 )
N
• normal stereocilia orientation at E18.5




Genotype
MGI:3831931
cx4
Allelic
Composition		 Dvl2tm1Awb/Dvl2+
Dvl3tm1Awb/Dvl3tm1Awb
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (33 available)
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
small heart ( J:142392 )
• at P0

craniofacial

embryo
short rostral-caudal axis ( J:142392 )
• at E18.5, mice exhibit shortening along the anterior-posterior axis
craniorachischisis ( J:142392 )
• in two mice

growth/size/body
herniated abdominal wall ( J:142392 )
• one mouse exhibited craniorachischisis, gastroschisis, and an absent tail
abnormal head morphology ( J:142392 )
short snout ( J:142392 )

hearing/vestibular/ear
abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )
• mice exhibit rotated stereocillia bundles and mild patterning defects compared to in wild-type mice
• defects are more severe in mice also displaying craniorachischisis

limbs/digits/tail
absent tail ( J:142392 )
• one mouse exhibited craniorachischisis, gastroschisis, and an absent tail

nervous system
craniorachischisis ( J:142392 )
• in two mice
abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )
• mice exhibit rotated stereocillia bundles and mild patterning defects compared to in wild-type mice
• defects are more severe in mice also displaying craniorachischisis




Genotype
MGI:3831932
cx5
Allelic
Composition		 Dvl2tm1Awb/Dvl2+
Dvl3tm1Awb/Dvl3+
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (33 available)
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiac outflow tract development ( J:142392 )
• at E18.5, 11 of 28 mice exhibit conotruncal defects
persistent truncus arteriosus ( J:142392 )
• in 1 of 11 mice
double outlet right ventricle ( J:142392 )
• in 9 of 11 mice

hearing/vestibular/ear

nervous system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory