Analysis Tools
immune system
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• in female mice
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• in female, but not male, mice
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• in female, but not male, mice
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• female mice exhibit a decrease in CD8alpha,beta T cells compared with wild-type mice
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• male mice exhibit an increase in CD8alpha,beta T cells compared with wild-type mice
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• in female mice
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• in female mice
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• in female mice
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• in female mice
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homeostasis/metabolism
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• in male mice
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• mice exhibit reduced metabolized energy compared with wild-type mice
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• Background Sensitivity: when normalized to individual body weight, male mice congenic on a C3 background exhibit increased metabolized energy while male mice exhibit only a tendency compared with wild-type mice whereas on a 129 background only female mice exhibit increased metabolized energy compared with wild-type mice
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• alpha-amylase activity is decreased compared to in wild-type mice
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skeleton
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• in one mouse
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• whole body bone mineral content is reduced in female mice and tends to be reduced in male mice compared with wild-type mice
• however, bone content related to body weight is normal
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• whole body bone mineral density is reduced compared to in wild-type mice
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• specific bone mineral density is increased compared to in wild-type mice
• however, bone content related to body weight is normal
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growth/size/body
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• average body lean body mass and the average fat to lean mass ratio are reduced compared to in wild-type mice
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• at 6 weeks, average body weight is decreased compared with wild-type mice
• average fat-free dry mass is reduced compared to in wild-type mice
• however, body weight normalized to energy uptake is normal
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• mice are shorter than wild-type mice
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• mice fasted for 2 days exhibit a greater loss of body weight compared with similarly treated wild-type mice
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cardiovascular system
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• pulse and heart rate in female mice are decreased compared to in wild-type mice
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• the Q amplitude is increased compared to in wild-type mice
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• at 14 weeks in male mice
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• at 14 weeks in male mice
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• at 14 weeks in male mice
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adipose tissue
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• average body fat content and the average fat to lean mass ratio are reduced compared to in wild-type mice
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behavior/neurological
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• mice consume less food and have a reduced energy uptake compared with wild-type mice
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• mice exhibit a tendency towards reduced locomotor activity compared with wild-type mice
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digestive/alimentary system
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• mice produce less feces than wild-type mice
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hematopoietic system
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• in female mice
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• in female, but not male, mice
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• in female, but not male, mice
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• female mice exhibit a decrease in CD8alpha,beta T cells compared with wild-type mice
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• male mice exhibit an increase in CD8alpha,beta T cells compared with wild-type mice
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• in female mice
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• in female mice
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• in female mice
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• in female mice
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